Figure 7 | Scientific Reports

Figure 7

From: Brain-enriched guanylate kinase-associated protein, a component of the post-synaptic density protein complexes, contributes to learning and memory

Figure 7

Impairment of retention of contextual memory in the BEGAIN-KO mice in the contextual cued fear conditioning test. (A) Total distance travelled (cm) in 6 s with electrical stimulation (2 s, black bar) for conditioning. The statistical analysis was carried out in the six seconds indicated. (B) Freezing responses by electrical shock (arrow) with cue tone (black bar) on the conditioning day (left; conditioning). Freezing responses in the contextual test on day 1 after conditioning (middle; context). Freezing responses in the cue test on day 1 after conditioning (right). (C) Freezing responses in the contextual test on day 28 after conditioning (left). Total distances in the cue test on day 28 after conditioning (right). Bold lines represent tone [right in (B) and right in (C)]. All values are presented as mean ± standard error of the mean. p-values indicate the genotype effect in two-way repeated-measures analysis of variance (ANOVA). Analyses were performed separately for pre-tone (1–3′) and cue-tone (4–6′) periods [right in (B) and right in (C)].

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