Figure 2
From: Impact of various high fat diets on gene expression and the microbiome across the mouse intestines
Differential expression of nuclear receptors across the intestinal tract and in different HFDs. (A) Non row-normalized heatmap showing levels of all 48 nuclear receptors (NR) across the tissues in mice fed VIV chow, sorted by levels in the duodenum (DUO) and compared to non NR transcription factors (*). Normalized read counts across three biological replicates are shown. JEJ Jejunum, TI Terminal Ileum, PC Proximal colon, Arrows genes plotted in figure. Arbitrary scale of relative expression is shown. See Supplementary Fig. S5 for additional heatmaps of nuclear receptors. (B) Line graphs showing normalized read counts with standard deviation (SD) of select NRs in various parts of the intestines on the indicated diets. Significantly different genes between diets within a given tissue (p-adj ≤ 0.05) are indicated as follows: a (VIV vs CO); b (VIV vs SO + CO); c (VIV vs PL + CO); d (CO vs SO + CO). (C) As in (B) but for beta-catenin (Ctnnb1).
