Figure 6
From: Impact of various high fat diets on gene expression and the microbiome across the mouse intestines
Impact of HFDs on the gut microbiome and related host genes. (A) Heatmap of significantly dysregulated genes involved in the microbiome response in the host. Included are genes that are significantly different between any two diets (p-adj ≤ 0.05). Solid arrows, plotted in this figure; open arrows, plotted in a subsequent figure. Arbitrary scale of relative expression is shown. See Supplementary Table S6 for a complete list of genes. (B) Line graphs showing normalized read counts with standard deviation (SD) of select genes in various parts of the intestines on the indicated diets. Genes with significantly different levels of expression between the diets within a given tissue (p-adj ≤ 0.05) are indicated as follows: (VIV, CO, SO + CO, PL + CO). a (VIV vs CO); b (VIV vs SO + CO); c (VIV vs PL + CO). (C) Taxa plots showing differentially abundant bacteria from host-associated intestinal epithelial cells in the small intestine or colon of mice fed the different diets (CO, SO + CO, PL + CO, VIV). Values in taxa plots are % IlluminaITS rRNA gene reads from intestinal epithelial cells from the indicated tissue. n = 11–12 mice for each of the four diets.
