Figure 8
From: Impact of various high fat diets on gene expression and the microbiome across the mouse intestines
Overview of impact of HFDs on microbiome and gene expression. (A) Overview of the role various HFDs may play in the development of disease by impacting the indicated pathways along the intestinal tract. SFA saturated fatty acids, MUFA monounsaturated fatty acids, PUFA polyunsaturated fatty acids. Image for microbiome obtained from Biorender.com. See “Discussion” for details. (B) Scatter plots showing normalized read counts of select intestinal transporters in various parts of the intestines on the indicated diets (VIV, CO, SO + CO, PL + CO). Line, mean of biological replicates. Genes with significantly different levels of expression between the diets within a given tissue (p-adj ≤ 0.02) are indicated as follows: a (VIV vs CO); b (VIV vs SO + CO); c (VIV vs PL + CO); f (SO + CO vs PL + CO). (C) As in B but for VIV, SO + CO and PL + CO diets. p-adj between SO + CO and PL + CO diets is indicated. Values for CO were higher than the other diets but had a very wide range and hence not plotted: see Supplementary Table S2 for numerical values.
