Table 1 Analysis of the correlation between PKM2 mRNA expression and prognosis of different clinicopathologic factors in lung cancer by Kaplan–Meier plotter.
From: PKM2 is a potential prognostic biomarker and related to immune infiltration in lung cancer
Clinicopathological factors | Overall survival | First progression | Post progression survival | ||||||
|---|---|---|---|---|---|---|---|---|---|
N | Hazard ratio | p value | N | Hazard ratio | p value | N | Hazard ratio | p value | |
Gender | |||||||||
Female | 808 | 1.69 (1.35–2.1) | 2.4e−06 | 500 | 2.5 (1.89–3.31) | 3.8e−11 | 193 | 1.57 (1.08–2.29) | 0.017 |
Male | 1247 | 1.69 (1.4–2.06) | 6.4e−08 | 752 | 1.75 (1.41–2.18) | 3.2e−07 | 284 | 1.28 (0.92–1.78) | 0.15 |
Histology | |||||||||
Adenocarcinoma | 1161 | 2.64 (2.06–3.38) | 1.1e−15 | 906 | 2.36 (1.93–2.89) | < 1E−16 | 376 | 1.41 (1.03–1.92) | 0.03 |
Squamous cell carcinoma | 780 | 1.36 (1.12–1.65) | 0.0021 | 220 | 1.47 (0.97–2.22) | 0.067 | 51 | 1.32 (0.74–2.37) | 0.34 |
Stage | |||||||||
1 | 656 | 2.38 (1.85–3.07) | 5.9e−12 | 325 | 2.18 (1.4–3.4) | 0.00042 | 78 | 2.52 (1.27–5.02) | 0.0065 |
2 | 392 | 2.08 (1.5 -2.88) | 6.3e−06 | 130 | 1.23 (0.73–2.06) | 0.44 | 58 | 2.16 (1.12–4.15) | 0.019 |
3 | 108 | 1.26 (0.76–2.08) | 0.37 | 19 | – | – | 10 | – | – |
4 | 4 | – | – | 0 | – | – | 0 | – | – |
AJCC_T | |||||||||
T1 | 429 | 2.03 (1.46–2.83) | 1.8e−05 | 338 | 3.08 (1.94–4.89) | 4.8e−07 | 111 | 0.66 (0.42–1.03) | 0.068 |
T2 | 578 | 1.31 (1.03–1.67) | 0.025 | 415 | 1.46 (1.12–1.92) | 0.0054 | 221 | 1.32 (0.95–1.83) | 0.095 |
T3 | 82 | 1.57 (0.93–2.63) | 0.087 | 48 | 2.08 (1.01–4.3) | 0.044 | 35 | 0.85 (0.41–1.75) | 0.66 |
T4 | 43 | 0.6 (0.31–1.17) | 0.13 | 25 | 0.36 (0.1–1.22) | 0.087 | 17 | - | - |
AJCC_N | |||||||||
N0 | 768 | 1.47 (1.17–1.86) | 0.00095 | 562 | 1.53 (1.16–2.02) | 0.0022 | 218 | 0.87 (0.63–1.21) | 0.41 |
N1 | 253 | 1.54 (1.11–2.15) | 0.01 | 181 | 2.62 (1.68–4.09) | 1e−05 | 105 | 1.72 (1.1–2.7) | 0.016 |
N2 | 104 | 1.12 (0.74–1.7) | 0.58 | 76 | 0.7 (0.39–1.26) | 0.23 | 55 | 0.6 (0.34–1.06) | 0.078 |
AJCC_M | |||||||||
M0 | 682 | 1.45 (1.18–1.79) | 0.00038 | 464 | 1.26 (0.93–1.71) | 0.13 | 159 | 1.16 (0.82–1.64) | 0.41 |
M1 | 10 | – | – | 6 | – | – | 4 | – | – |
Grade | |||||||||
I | 188 | 1.34 (0.89–2.02) | 0.17 | 136 | 0.7 (0.43–1.14) | 0.15 | 88 | 1.93 (1.2–3.1) | 0.0058 |
II | 302 | 1.86 (1.31–2.63) | 0.00043 | 166 | 1.45 (0.97–2.17) | 0.07 | 106 | 1.4 (0.89–2.18) | 0.14 |
III | 75 | 3.11 (1.58–6.14 | 0.00057 | 52 | 0.54 (0.22–1.3) | 0.16 | 28 | 0.25 (0.07–0.89) | 0.021 |
Smoking history | |||||||||
Yes | 833 | 1.72 (1.39–2.12) | 4.6e−07 | 584 | 1.97 (1.54–2.52) | 4.4e−08 | 266 | 1.28 (0.94–1.75) | 0.12 |
No | 204 | 4.56 (2.27–9.16) | 3.1e−06 | 190 | 3.72 (2.18–6.36) | 2.6e−07 | 70 | 2.31 (1.22–4.35 | 0.0081 |
Chemotherapy | |||||||||
Yes | 173 | 1.97 (1.29–2.99) | 0.0013 | 122 | 1.67 (1.04–2.69) | 0.032 | 88 | 2.06 (1.25–3.37) | 0.0036 |
No | 400 | 1.63 (1.22–2.19) | 0.00095 | 285 | 1.29 (0.87–1.92) | 0.2 | 153 | 1.43 (0.92–2.23) | 0.11 |
Radiotherapy | |||||||||
Yes | 65 | 2.74 (1.51–4.99) | 6e−04 | 62 | 1.51 (0.81–2.82) | 0.19 | 54 | 2.02 (1.08–3.77) | 0.025 |
No | 363 | 1.24 (0.92–1.67) | 0.16 | 289 | 0.97 (0.7–1.35) | 0.87 | 163 | 1.12 (0.78–1.6 | 0.53 |
Surgery success | |||||||||
Only surgical margins negative | 704 | 3.03 (2.27–4.04) | 2.1e−15 | 558 | 4.8 (3.18–7.26) | 2.2e−16 | 276 | 1.51 (1.13–2.04) | 0.0057 |
