Figure 4 | Scientific Reports

Figure 4

From: Inhibition of Drp1 orchestrates the responsiveness of breast cancer cells to paclitaxel but insignificantly relieves paclitaxel-related ovarian damage in mice

Figure 4

Computational modeling of the molecular interactions of paclitaxel, and mdivi-1 with mitochondrial redox-related enzymes. The 2D interaction diagrams demonstrate the interaction of ligands (PTX or mdivi-1) with mitochondrial ATP synthase, SOD or Thioredoxin reductase 1. The hot spots in protein domains, the superimposition of the docking pose, and the co-crystallized ligands in the active sites in the enzyme active site are shown. The docking score is shown next each protein.

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