Table 1 Demographic characteristics of rats following intravitreal injection of ET-1.

Number of rats, n

7

5

16

7

–

Intraocular pressure, mmHg

6.2 ± 0.7

6.3 ± 0.8

5.4 ± 0.5

5.3 ± 0.7

0.600

Mean BP, mmHg

79.2 ± 4.9

86.4 ± 5.8

84.4 ± 3.6

86.7 ± 4.9

0.707

Systolic BP, mmHg

91.4 ± 6.0

100.5 ± 7.1

100.1 ± 4.4

100.3 ± 6.0

0.639

Diastolic BP, mmHg

73.1 ± 4.4

78.8 ± 5.3

76.6 ± 3.3

79.9 ± 4.4

0.726

Ocular perfusion pressure, mmHg

46.6 ± 3.3

51.1 ± 3.9

50.9 ± 2.4

52.5 ± 3.3

0.625

Heart rate, bpm

232.1 ± 22.9

255.2 ± 40.5

257.5 ± 15.4

236.6 ± 25.1

0.095

% Vessel-area MBR, % (Vessel-area MBR, AU)

100.0 ± 20.7 (68.1 ± 5.1)

93.9 ± 24.0 (63.9 ± 6.1)

54.5 ± 21.2 (37.1 ± 3.4)

14.6 ± 11.3 (10.0 ± 5.1)

 < 0.0001*

% Tissue-area MBR, % (Tissue-area MBR, AU)

100.0 ± 43.5 (16.5 ± 7.2)

83.4 ± 19.1 (13.7 ± 3.1)

51.4 ± 16.7 (8.5 ± 2.7)

22.5 ± 13.5 (3.7 ± 2.2)

 < 0.0001*

% Overall-area MBR, % (Overall-area MBR, AU)

100.0 ± 12.2 (48.8 ± 6.0)

93.2 ± 27.9 (45.5 ± 13.6)

41.0 ± 18.4 (20.0 ± 9.0)

11.7 ± 7.9 (5.70 ± 3.9)

 < 0.0001*