Figure 5
From: Myeloid deletion of talin-1 reduces mucosal macrophages and protects mice from colonic inflammation
Tln1fl/fl mice exhibit increased macrophage differentiation in the infected colon compared to Tln1Δmye mice. Cells isolated from the colonic lamina propria of Tln1fl/fl and Tln1Δmye mice infected with C. rodentium or mock, were assessed by flow cytometry for P1, P2, and P3/4 differentiation makers (A). Data shown are the concatenated results from all mice in the experiment. The frequency of Ly6C–MHCII+ macrophages (P3/4) is depicted in (B). n = 2–3 uninfected mice and n = 5–7 infected mice per genotype. All values are reported as mean ± SEM. Statistical analyses, *P < 0.05 determined by 1-way ANOVA with a Kruskal–Wallis test, followed by Mann–Whitney U tests.
