Figure 2 | Scientific Reports

Figure 2

From: Peri-implantitis increases the risk of medication-related osteonecrosis of the jaws associated with osseointegrated implants in rats treated with zoledronate

Figure 2

Immunolabeling for TRAP in peri-implant bone tissue. (a) Graph showing the number of TRAP-positive cells/mm2 of bone tissue. (b–e) Photomicrographs showing the immunolabeling pattern for TRAP in the peri-implant bone tissue in groups VEH (b), VEH-EPI (c), ZOL (d) and ZOL-EPI (e). (f–g) Photomicrographs highlighting the differences between osteoclasts from the vehicle-treated and zoledronate-treated groups, in which such cells appear much larger, hypernucleated, rounded and distant from the bone matrix. Statistical test used: Variance Analysis (ANOVA) followed by Tukey post-test. Symbols: black arrows, TRAP-positive cells (osteoclasts); †statistically significant difference in relation to the VEH group; ‡statistically significant difference in relation to the VEH-EPI group. Counterstain: Harris Hematoxylin. Original magnification: (b–e) 1000 × ; (f–g) 4000 × . Scale bars: (b–e) 25 μm; (f–g) 10 µm.

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