Figure 1

Platelet activation in WB exposed to hormone therapy-treated breast cancer cell lines. Untreated MCF7 and T47D cells induced platelet activation in WB. Note pseudopodia extension and hyalomere spread, more so than that evidenced in control WB. Exposure of WB to either Anastrozole or Tamoxifen-treated breast cancer cells resulted in further platelet activation, aggregation and membrane disruption. Key: black *membrane folds, white *hyalomere spread, white arrowextending filipodia, black arrowmicroparticles.