Figure 3

Molecular clustering of osteosarcoma based on CIC-related epigenetic factors. (A, B) The rank curve and heatmap of NMF clustering. (C) KM curve of osteosarcoma patients in different molecular subtypes. (D) 3D dot plot of PCA analysis. (E) The plot of GSVA analysis based on the KEGG database. The blue columns present the top 15 KEGG pathways with the highest t-value, and the green columns present the top 15 KEGG pathways with the lowest t-value. (F) The result of GSEA based on the GO database. The top 5 terms of cellular component (CC), molecular function (MF), and biological process (BP) enriched in Cluster 1 and Cluster 2 were presented.