Figure 6 | Scientific Reports

Figure 6

From: A CIC-related-epigenetic factors-based model associated with prediction, the tumor microenvironment and drug sensitivity in osteosarcoma

Figure 6

The construction and validation of predictive nomogram. (A) The nomogram for predicting 1-, 3-, and 5-year overall survival, was constructed based on age, gender, metastasis, and risk score of patients from the TARGET cohort. Each feature of patients corresponds to a score on the Point scale, and the final score on the Total Points scale results from the addition of the above scores, which corresponds to the survival probability. Point scale: 0–100. The score assigned to each of the characteristics: Age (0.00–1.87); Gender (Male: 0.00; Female: 1.53); Metastasis (No: 0.00; Yes: 25.00); riskScore (0.00–100.00). (B) The calibration curve of the nomogram in terms of the agreement between predicted and observed outcomes in the TARGET cohort. (C) The time dependent ROC curves of age, gender, metastasis, risk score and nomogram with AUC values of 0.496, 0.525, 0.576, 0.696, and 0.766 at 5 years in the TARGET cohort. (D) The calibration of nomogram in the GSE21257 cohort. (E) The ROC curves of age, gender, metastasis, risk score and nomogram with AUC values of 0.480, 0.523, 1.000, 0.772, 0.884 at 5 years in the GSE21257 cohort.

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