Figure 3 | Scientific Reports

Figure 3

From: Proteomic analysis reveals activation of platelet- and fibrosis-related pathways in hearts of ApoE−/− mice exposed to diesel exhaust particles

Figure 3

Bioinformatic analysis of differentially expressed proteins. (A) Top five biological process and molecular function terms enriched in the 39 proteins significantly increased (P-value < 0.05, > 1.3-fold) in DEP-treated ApoE−/− mice relative to PBS-treated ApoE−/− mice, as identified by Gene Enrichment (GO) enrichment analysis. (B) Top three interaction networks generated by ingenuity pathway analysis (IPA) are shown, respectively, in (a), (b), and (c). Proteins that significantly increased (P-value < 0.05, > 1.3-fold) in DEP-treated ApoE−/− mice in comparison to PBS-treated ApoE−/− mice are represented in red. TGF beta, ERK1/2, and TGFB1/NFκB were identified as the major hubs in each network. Straight lines denote direct interactions, and dashed lines denote indirect interactions.

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