Table 2 Univariate analyses of OS in the training datasets.
From: Prognostic value of normal levels of preoperative tumor markers in colorectal cancer
Variables | β | HR (95%CI) | P-value |
|---|---|---|---|
Age (years) | |||
< 70 | Reference | ||
≥ 70 | 0.582 | 1.789 (1.382–2.318) | < 0.001 |
Gender | |||
Male | Reference | ||
Female | − 0.027 | 0.973 (0.757–1.251) | 0.832 |
Tumor size (cm) | |||
< 5 | Reference | ||
≥ 5 | –0.198 | 0.821 (0.619–1.088) | 0.170 |
Operative method | |||
Open | Reference | ||
Laparoscopic | − 0.014 | 0.986 (0.762–1.275) | 0.914 |
Tumor location | 0.010 | ||
Right-sided colon | Reference | ||
Left-sided colon | 0.377 | 1.459 (0.930–2.287) | 0.100 |
Rectum | 0.579 | 1.784 (1.217–2.615) | 0.003 |
Differentiation status | 0.004 | ||
Well | Reference | ||
Moderate | − 0.018 | 0.982 (0.672–1.436) | 0.927 |
Poor | 0.649 | 1.914 (1.184–3.093) | 0.008 |
Mucinous | 0.155 | 1.168 (0.683–1.996) | 0.570 |
T stage | < 0.001 | ||
Tis/T1 | Reference | ||
T2 | 0.420 | 1.523 (0.811–2.858) | 0.191 |
T3 | 1.073 | 2.924 (1.662–5.142) | < 0.001 |
T4 | 1.847 | 6.338 (3.360–11.955) | < 0.001 |
N stage | < 0.001 | ||
N0 | Reference | ||
N1 | 0.842 | 2.321 (1.734–3.106) | < 0.001 |
N2 | 1.684 | 5.384 (3.967–7.308) | < 0.001 |
Preoperative CEA | |||
< 2.9 ng/mL | Reference | ||
≥ 2.9 ng/mL | 0.459 | 1.582 (1.227–2.041) | < 0.001 |
Preoperative AFP | |||
< 1.8 ng/mL | Reference | ||
≥ 1.8 ng/mL | − 0.214 | 0.807 (0.622–1.048) | 0.107 |
Preoperative CA125 | |||
< 13.4 U/mL | Reference | ||
≥ 13.4 U/mL | 0.346 | 1.414 (1.093–1.829) | 0.008 |
Preoperative CA19-9 | |||
< 10.1 U/mL | Reference | ||
≥ 10.1 U/mL | 0.550 | 1.733 (1.351–2.223) | < 0.001 |
