Figure 2
From: AMPKα2 regulates fasting-induced hyperketonemia by suppressing SCOT ubiquitination and degradation
Deletion of skeletal muscle AMPKα2 enhances fasting-induced hyperketonemia. (A–D) Blood BHB, urine ketone, blood glucose levels and body weights in littermate, AMPKα1ΔMusc, and AMPKα2ΔMusc mice during 2-day fasting. (E–H) Blood BHB, urine ketone, blood glucose levels and body weights in littermate, AMPKα1ΔMyo, and AMPKα2ΔMyo mice during 2-day fasting (n = 9–17 in each group). (I–L) Blood BHB and urine ketone levels in littermate, AMPKα1ΔMusc, AMPKα2ΔMusc, AMPKα1ΔMyo, and AMPKα2ΔMyo mice after BHB administration. Littermate means littermate control mice. Values represent the mean ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001 vs. control mice.
