Figure 3 | Scientific Reports

Figure 3

From: Characterization of Wnt signaling pathway under treatment of Lactobacillus acidophilus postbiotic in colorectal cancer using an integrated in silico and in vitro analysis

Figure 3

DEG and Enrichment analysis. (A) The ranking of identifying total DEGs between the normal and adenocarcinoma samples. (B,C) KEGG and GO analysis showed that the Wnt signaling pathway is one of the critical regulators of CRC. (D) The ExpiMap also approved the Wnt signaling pathway in COAD. (E) The dot plot shows that the Wnt signaling pathway is more activated in control compared to the COAD group in total cells (F), which is mainly activated in fibroblast cells. (G) The dot plot also shows that the Wnt pathway is mainly activated in fibroblasts of normal cells rather than COAD cells (H) which was validated through the UMAP plot. (I) The volcano plot shows that four genes, including SFRP1, SFRP2, SFRP4, and MMP7, are involved in the Wnt pathway. (J) The dot plot visualized the expression patterns of selected DEGs in the COAD tissues compared to the control group. The expression of MMP7 has increased in the COAD group, while SFRP1, SFRP2, and SFRP4 genes had higher levels of expression in the control group (K). The dot plot demonstrated that the selected DEGs are mainly expressed in fibroblast. (L) The dot plot of the expression patterns of the selected DEGs in different cell cycle phases.

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