Table 2 Causal effects of education and smoking on vascular dementia via multivariable IVW MR analyses.
MVMR | Disease | SNPs | MVMR-IVW OR (95%CI) | P | MVMR-Egger OR (95%CI) | P | Intercept |
|---|---|---|---|---|---|---|---|
MVMR1 | COPD | 106 | 0.276 (0.141–0.537) | 0.001 | 0.261 (0.133–0.511) | 0.001 | 0.162 |
IPF | 92 | 5.215 (2.698–7.731) | 0.001 | 4.973 (2.435–7.521) | 0.001 | 0.219 | |
Asthma | 106 | 0.531 (0.348–0.811) | 0.003 | 0.522 (0.339–0.799) | 0.003 | 0.679 | |
MVMR2 | COPD | 52 | 0.180 (0.096–0.340) | 0.001 | 0.288 (0.098–0.848) | 0.024 | 0.294 |
IPF | 32 | 4.514 (1.898–7.130) | 0.001 | 4.374 (1.723–7.026) | 0.001 | 0.529 | |
Asthma | 52 | 0.631 (0.355–1.122) | 0.117 | -0.832 (0.311–2.223) | 0.715 | 0.496 | |
MVMR3 | COPD | 112 | 0.185 (0.090–0.378) | 0.001 | 0.192 (0.094–0.392) | 0.001 | 0.240 |
IPF | 100 | 5.026 (2.544–7.508) | 0.001 | 4.837 (2.377–7.370) | 0.001 | 0.294 | |
Asthma | 112 | 0.565 (0.339–0.943) | 0.994 | 0.565 (0.342–0.934) | 0.026 | 0.921 |
