Table 6 Significant change in protein acetylated modification after fructose exposure in rat liver.

From: The effect of fructose exposure on amino acid metabolism among Chinese community residents and its possible multi-omics mechanisms

Protein name

Acetylated location

MotifSequence

Fold regulation

P value

Corrected P value#

Pecr

K92

EVNNLVKSTLAKY

135.37

0.5*10–3

0.04

Tkt

K236

QVDVYQKRCEAFG

91.06

0.6*10–3

0.04

Atp5f1a

K531

NIRSDGKISEQSD

88.89

0.1*10–3

0.02

Slc25a12

K384

APEKAIKLTVNDF

85.48

0.8*10–4

0.01

Hibch

K352

RAVLIDKDQTPKW

78.53

0.3*10–7

0.3*10–2

Acat1

K199

CAENTAKKLSISR

67.83

0.1*10–4

0.7*10–2

Acadsb

K284

KIGHGYKYAIGSL

50.29

0.8*10–4

0.01

Gstt2

K52

SQVNCLKKVPVLK

49.30

0.2*10–4

0.8*10–2

Acaa2

K269

SEDAVKKHNFTPL

33.25

0.7*10–4

0.01

Ivd

K240

GFSTSKKLDKLGM

32.87

0.1*10–4

0.5*10–2

Got2

K302

KDAEEAKRVESQL

31.34

0.3*10–4

0.8*10–2

Hsd17b10

K52

EGETEAKKLGGNC

28.14

0.5*10–3

0.04

Glul

K333

RIVGQEKKGYFED

26.81

0.1*10–4

0.5*10–2

Dld

K267

FQRILQKQGFKFK

23.13

0.7*10–4

0.01

Suox

K495

WRIWQLKAHVPAE

21.67

0.4*10–3

0.04

Tcp1

K400

DALCVVKRVLESK

19.22

0.1*10–4

0.6*10–2

Myh4

K914

RCDQLIKTKIQLE

18.21

0.9*10–4

0.01

Suclg2

K278

IFAMDDKSENEPI

17.09

0.1*10–3

0.02

Mybpc1

K479

GKEVCLKCEISEN

16.31

0.2*10–3

0.03

Pdhx

K488

RFRPVLKLTEDEE

15.70

0.2*10–7

0.5*10–2

Farsb

K317

ADLINKKVGIKET

14.61

0.3*10–3

0.03

Hadh

K249

DIDTAMKLGAGYP

13.98

0.3*10–3

0.03

Plec

K768

QDAQDEKEQLNEY

13.95

0.1*10–4

0.5*10–2

H1f2

K64

SLAALKKALAAAG

13.27

0.6*10–3

0.04

Letmd1

K209

ALVSNEKLRWHLE

12.49

0.3*10–4

0.9*10–2

Slc25a1

K268

CGVQILKNEGPKA

9.46

0.5*10–3

0.04

Hsd17b4

K275

VRDNWVKICDFSN

9.34

0.6*10–4

0.01

Hspd1

K359

DDAMLLKGKGDKA

9.23

0.8*10–3

0.05

Ak3

K165

IQREDDKPETVIK

8.56

0.4*10–7

0.3*10–2

Hadha

K411

FKGLNDKVKKKAL

8.53

0.6*10–3

0.04

Nln

K134

ETCDLEKIKPEAR

7.75

0.7*10–3

0.05

Snd1

K514

GDTQKAKQFLPFL

7.58

0.7*10–3

0.05

Idh2

K45

YAEKRIKVEKPVV

7.26

0.2*10–3

0.03

Bckdhb

K293

ASMAQEKLGVSCE

7.13

0.4*10–2

0.05

Macroh2a1

K234

LGSTLEKKGGKEF

7.07

0.6*10–4

0.01

Glrx5

K147

SALIDEKDQDSK_

6.93

0.7*10–3

0.05

Clpx

K475

HQDIEEKDRLLRH

6.64

0.2*10–3

0.03

Sardh

K885

VSLDFVKNGDYAL

6.53

0.1*10–3

0.02

Aldh1l2

K227

TYEGIQKKENAEI

5.47

0.1*10–4

0.7*10–2

Psmd11

K382

SLADFEKALTDYR

4.84

0.9*10–3

0.05

Cs

K321

LQKEVGKDVSDEK

4.69

0.2*10–3

0.03

Gmppa

K384

SLFKDGKLLPAIT

4.18

0.6*10–3

0.04

Ndufa10l1

K191

DHYNEIKRLTLPE

4.11

0.1*10–3

0.02

Pygl

K724

DVAALDKKGYEAK

3.45

0.4*10–3

0.04

Hspe1

K35

GIMLPEKSQGKVL

2.99

0.5*10–3

0.04

Bckdk

K233

PKKIIEKWVDFAR

2.01

0.5*10–3

0.04

Trip13

K243

QDLIDDKEALVFV

0.43

0.3*10–3

0.03

Otc

K231

PDPNIVKLAEQYA

0.21

0.3*10–3

0.03

  1. Abbr.: peroxisomal trans-2-enoyl-CoA reductase (Pecr); transketolase (Tkt); ATP synthase F1 subunit alpha (Atp5f1a); solute carrier family 25 member 12 (Slc25a12); 3-hydroxyisobutyryl- CoA hydrolase (Hibch); acetyl-CoA acetyltransferase 1 (Acat1); acyl-CoA dehydrogenase, short/branched chain (Acadsb); glutathione S-transferase, theta 2 (Gstt2); acetyl-CoA acyl- transferase 2 (Acaa2); isovaleryl-CoA dehydrogenase (Ivd); glutamic-oxaloacetic transaminase 2 (Got2); hydroxysteroid (17-beta) dehydrogenase 10 (Hsd17b10); glutamate-ammonia ligase (Glul); dihydrolipoamide dehydrogenase (Dld); sulfite oxidase (Suox); t-complex 1 (Tcp1); myosin heavy chain 4 (Myh4); succinate-CoA ligase, GDP-forming, beta subunit (Suclg2); myosin binding protein C, slow type (Mybpc1); pyruvate dehydrogenase complex, component X (Pdhx); phenylalanyl-tRNA synthetase subunit beta (Farsb); hydroxyacyl-CoA dehydrogenase (Hadh); plectin (Plec); H1.2 linker histone, cluster member (H1f2); LETM1 domain containing 1 (Letmd1); solute carrier family 25 member 1 (Slc25a1); hydroxysteroid (17-beta) dehydrogenase 4 (Hsd17b4); heat shock protein family D (Hsp60) member 1 (Hspd1); adenylate kinase 3 (Ak3); hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha (Hadha); neurolysin (Nln); staphylococcal nuclease and tudor domain containing 1 (Snd1); isocitrate dehydrogenase (NADP( +)) 2 (Idh2); branched chain keto acid dehydrogenase E1 subunit beta (Bckdhb); macroH2A.1 histone (Macroh2a1); glutaredoxin 5 (Glrx5); caseinolytic mitochondrial matrix peptidase chaperone subunit (Clpx); sarcosine dehydrogenase (Sardh); aldehyde dehydrogenase 1 family, member L2 (Aldh1l2); proteasome 26S subunit, non-ATPase 11 (Psmd11); citrate synthase (Cs); GDP-mannose pyrophosphorylase A (Gmppa); NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10-like 1 (Ndufa10l1); glycogen phosphorylase L (Pygl); heat shock protein family E (Hsp10) member 1 (Hspe1); branched chain ketoacid dehydrogenase kinase (Bckdk); thyroid hormone receptor interactor 13 (Trip13); ornithine carbamoyltransferase (Otc).
  2. #P value with Benjamin Hochberg correction.
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