Table 2 GRADE summary of findings.
Intravenous iron compared to Oral Iron for Rise in Hb | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Participants (studies) Follow-up | Risk of bias | Inconsistency | Indirectness | Imprecision | Publication bias | Overall certainty of evidence | |||||
8061 (34 RCTs) | Not serious | Not serious | Not serious | Not serious | None | ⨁⨁⨁⨁ High | |||||
Intravenous iron compared to Oral Iron for preventing adverse maternal outcome | |||||||||||
Certainty assessment | Summary of findings | ||||||||||
Participants (studies) Follow-up | Risk of bias | Inconsistency | Indirectness | Imprecision | Publication bias | Overall certainty of evidence | Study event rates (%) | Relative effect (95% CI) | Anticipated absolute effects | ||
With Oral Iron | With Intravenous iron | Risk with Oral Iron | Risk difference with Intravenous iron | ||||||||
22,152 (19 RCTs) | Not serious | Serious a | Not seriousb | Not serious | None | ⨁⨁⨁◯ Moderate | 461/11,323 (4.1%) | 337/10,829 (3.1%) | OR 0.79 (0.66 to 0.95) | 41 per 1000 | 8 fewer per 1000 (from 13 to 2 fewer) |
Intravenous iron compared to Oral Iron for preventing adverse neonatal Outcome | |||||||||||
4961 (9 RCTs) | Not serious | Serious a | Not serious | Serious c | None | ⨁⨁◯◯ Low | 583/2496 (23.4%) | 566/2465 (23.0%) | OR 0.99 (0.86 to 1.14) | 234 per 1000 | 2 fewer per 1000 (from 26 fewer to 24 more) |
Intravenous iron compared to Oral Iron for preventing adverse events (reactions) | |||||||||||
13,909 (29 RCTs) | Not serious | Serious a | Not serious | Not serious | Publication bias strongly suspected c | ⨁⨁◯◯ Low | 1071/6931 (15.5%) | 678/6978 (9.7%) | OR 0.39 (0.26 to 0.60) | 155 per 1000 | 88 fewer per 1000 (from 109 to 56 fewer) |
