Figure 2 | Scientific Reports

Figure 2

From: Mutations associated with autism lead to similar synaptic and behavioral alterations in both sexes of male and female mouse brain

Figure 2

Synaptic, glutamatergic and GABAergic proteins reduction in both male and female Shank3−/− mouse models of ASD. (A and B) Representative western blots of synaptic proteins Syp, NR1, GAD1, VGAT, in Shank3−/− and WT mice. β-actin was used as a reference for protein loading. (C) Statistical analysis of the relative abundance of Syp proteins in all groups, [F3,12 = 0.6369]. (D) Statistical analysis of the relative abundance of NR1 proteins in all groups, [F3,12 = 1.602]. (E) Statistical analysis of the relative abundance of GAD1 proteins in all groups, [F3,12 = 0.6422). (F) Statistical analysis of the relative abundance of VGAT proteins in all groups, [F3,12 = 0.2450]. One-way Anova along with the Bonferroni multiple comparison tests was used for the western blot analyses in all groups. *p < 0.05, **p < 0.01, ***p < 0.001. n = 4 in all groups.

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