Table 5 Gene ontologies (GOs) and canonical pathways associated with the predicted gene targets for the differentially expressed miRNAs in each comparison.
Comparison | Analysis | GO/pathway | Description | Gene ratio | p-adjusted value | Gene ID |
|---|---|---|---|---|---|---|
Focal lesions vs controls | Cluster profiler | bta03020 | RNA polymerase | 2/15 | 0.03291 | POLR1E, POLR3G |
Diffuse vs focal lesions | Cluster profiler | bta04010 | MAPK signaling pathway | 12/105 | 0.02923 | TRADD, MAPKAPK2, MAP4K1, RASGRP3, TP53, TRAF6, ANGPT1, CSF1, RAC2, CACNB4, IGF2, PDGFB |
String | GO:0002682 | Regulation of immune system process | 29/1158 | 0.0094 | CACNB4, NLRC5, CXCL14, SIRPA, PLCL2, RAC2, CYP19A1, IL13, TRAF6, IL7, RBCK1, PIK3AP1, CD200, CNN2, EPHB6, TNFSF14, C2, NCKAP1L, CD84, ARG2, CSF1, EGR3, IL12B, NR1H3, STK10, IGF2, STAT1, CDK6, MAPKAPK2 | |
GO:0005730 | Nucleolus | 22/832 | 0.0138 | ZNRF2, TP53, LIN28A, POLR2F, VRK3, SPC24, TOP1, NFIB, CDKN2AIPNL, ZMAT3, SRP19, CCDC86, CDCA8, SDHAF2, DCTN3, MRPL40, MYCN, CCDC137, NFKBIE, EDF1, STAT1, DDX46 | ||
bta04010 | MAPK signaling pathway | 12/267 | 0.0027 | TP53, CACNB4, RAC2, TRADD, ANGPT1, TRAF6, PDGFB, CSF1, RASGRP3, IGF2, MAPKAPK2, MAP4K1 | ||
bta05200 | Pathways in cancer | 16/488 | 0.0027 | TP53, TPM3, RAC2, IL13, TRAF6, IL7, CCND1, GNGT2, PDGFB, IL12B, RASGRP3, IGF2, STAT1, CDK6, FZD3, WNT4 | ||
bta05167 | Kaposi sarcoma-associated herpesvirus infection | 9/175 | 0.0046 | TP53, ICAM1, TRADD, CCND1, GNGT2, PDGFB, STAT1, CDK6, MAPKAPK2 | ||
bta05160 | Hepatitis C | 8/150 | 0.0072 | TP53, TRADD, TRAF6, CCND1, CLDN11, NR1H3, STAT1, CDK6 | ||
bta05162 | Measles | 7/136 | 0.0197 | TP53, TRADD, TRAF6, CCND1, IL12B, STAT1, CDK6 | ||
bta05169 | Epstein–Barr virus infection | 8/197 | 0.0283 | TP53, ICAM1, TRADD, TRAF6, CCND1, NFKBIE, STAT1, CDK6 | ||
bta05212 | Pancreatic cancer | 5/69 | 0.0283 | TP53, RAC2, CCND1, STAT1, CDK6 | ||
bta04115 | p53 signaling pathway | 5/74 | 0.0289 | TP53, RRM2, ZMAT3, CCND1, CDK6 | ||
bta04142 | Lysosome | 6/119 | 0.0308 | CLTA, NAGPA, ASAH1, CTSA, PSAP, CTSW | ||
bta04151 | PI3K-Akt signaling pathway | 10/332 | 0.0308 | TP53, ANGPT1, IL7, CCND1, PIK3AP1, GNGT2, PDGFB, CSF1, IGF2, CDK6 | ||
bta04630 | JAK-STAT signaling pathway | 7/163 | 0.0308 | IL13, IL7, CCND1, IL21R, PDGFB, IL12B, STAT1 |
