Table 2 Rate of BPD, and secondary outcomes (durations of MV and oxygen therapy, re-intubation rate, incidence of complications, electrolytes and acid–base disturbances, length of hospital stay, mortality rate).
LISA + SNIPPV (n = 32) | InSurE + CPAP (n = 57) | P-value | |
|---|---|---|---|
Primary outcome | |||
Rate of BPD | 10 (31.25%) | 21 (36.84%) | 0.65 |
Secondary outcomes | |||
Duration of MV (days) | 12.18 ± 13.89 | 11.35 ± 11.61 | 0.76 |
Duration of oxygen therapy (days) | 35.03 ± 19.13 | 39.75 ± 17.91 | 0.25 |
Re-intubation rate | 0.19 ± 0.40 | 0.21 ± 0.45 | 0.81 |
Length of hospital stay (days) | 45.97 ± 16.93 | 54.40 ± 16.26 | 0.02* |
Mortality rate | 1 (3.13%) | 2 (3.51%) | 0.13 |
Complications | |||
Pneumothorax | 0 (0.00%) | 2(3.51%) | 0.53 |
Pneumonia | 18 (56.25%) | 22 (38.60%) | 0.11 |
Sepsis | 4 (12.50%) | 6 (10.53%) | 0.74 |
Nosocomial infection | 2 (6.25%) | 2 (3.51%) | 0.62 |
PDA | 24 (75.00%) | 27 (47.37%) | 0.01* |
PDA closure | 15 (60.00%) | 6 (20.69%) | 0.01* |
Cholestasis | 4 (12.50%) | 15 (26.32%) | 0.13 |
Cerebral hemorrhage | 20 (62.50%) | 36 (63.16%) | 0.95 |
NEC | 3 (9.38%) | 9 (15.79%) | 0.53 |
Pulmonary hemorrhage | 1 (3.13%) | 2 (3.51%) | 1.00 |
ROP | 2 (6.45%) | 5 (10.00%) | 0.70 |
Apnea | 25 (78.13%) | 36 (63.16%) | 0.14 |
PVL | 1 (3.13%) | 2 (3.51%) | 1.00 |
Anemia | 26 (81.25%) | 54 (94.74%) | 0.07 |
Hypoglycemia | 9 (28.13%) | 11 (19.30%) | 0.34 |
Elevated transaminases | 1 (3.23%) | 19 (33.33%) | 0.00* |
Electrolyte disturbances | |||
Hypocalcemia | 27 (84.38%) | 39 (68.42%) | 0.09 |
Hypophosphatemia | 8 (25.00%) | 6 (10.53%) | 0.07 |
Hypokalemia | 8 (25.00%) | 8 (14.04%) | 0.19 |
Hyperkalemia | 9 (28.13%) | 10 (17.54%) | 0.24 |
Hypochloremia | 6 (18.75%) | 20 (35.09%) | 0.10 |
Hypernatremia | 4 (12.50%) | 6 (10.53%) | 0.74 |
Hypermagnesemia | 12 (37.50%) | 11 (19.30%) | 0.05 |
Hypomagnesemia | 19 (59.38%) | 32 (56.14%) | 0.76 |
Acid–base disturbances | |||
Respiratory acidosis | 8 (25.00%) | 49 (85.96%) | < 0.001* |
Metabolic acidosis | 5 (15.63%) | 36 (63.16%) | < 0.001* |
Respiratory alkalosis | 0 (0.00%) | 10 (17.54%) | 0.01* |
Metabolic alkalosis | 0 (0.00%) | 26 (45.61%) | < 0.001* |
