Table 5 Feature importances for the classifier predicting MGD level 4 from relative protein quantifications using SHAP weighted by model uncertainty.

From: Using machine learning model explanations to identify proteins related to severity of meibomian gland dysfunction

Rank

Protein (accession number), incl. BL

Protein (accession number), excl. BL

1

Heterogeneous nuclear ribonucleoprotein M (P52272)

Heterogeneous nuclear ribonucleoprotein M (P52272)

2

Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (Q8TBX8)

Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (Q8TBX8)

3

Polymeric immunoglobulin receptor (P01833)

Polymeric immunoglobulin receptor (P01833)

4

Golgi membrane protein 1 (Q8NBJ4)

Golgi membrane protein 1 (Q8NBJ4)

5

Corticosteroid-binding globulin (P08185)

PRP4 (Q16378)

6

PRP4 (Q16378)

Immunoglobulin heavy variable 3-74 (A0A0B4J1X5)

7

Immunoglobulin heavy variable 3-74 (A0A0B4J1X5)

Corticosteroid-binding globulin (P08185)

8

Immunoglobulin heavy constant gamma 4 (P01861)

Mitogen-activated protein kinase 1 (P28482)

9

Malate dehydrogenase, cytoplasmic (P40925)

Malate dehydrogenase, cytoplasmic (P40925)

10

X-ray repair cross-complementing protein 5 (P13010)

Immunoglobulin heavy constant gamma 4 (P01861)

11

Mitogen-activated protein kinase 1 (P28482)

Eukaryotic translation initiation factor 6 (P56537)

12

Phospholipid transfer protein (P55058)

Methanethiol oxidase (Q13228)

13

Eukaryotic translation initiation factor 6 (P56537)

X-ray repair cross-complementing protein 5 (P13010)

14

Methanethiol oxidase (Q13228)

Phospholipid transfer protein (P55058)

15

Protein NDRG1 (Q92597)

Prostaglandin reductase 1 (Q14914)

  1. Bold font: Not among the original top ranked features. BL, borderline predictions.