Figure 3
From: Deficiency of the lipid flippase ATP10A causes diet-induced dyslipidemia in female mice
Atp10A deletion causes diet-induced dyslipidemia in female mice after 12 weeks of HFD. (a–c) Free fatty acids (FFA), cholesterol (chol), and triglycerides (TG) were measured in plasma from females after a 5 h fast or after a 5 h fast followed by an OGTT (a, 10A+/+ n = 12, 10A−/− n = 9,*P = 0.0320; b, 10A+/+ n = 12, 10A−/− n = 9, **P = 0.0030; c, 10A+/+ n = 12, 10A−/− n = 9, *P = 0.0165.) (d–f) Lipoproteins in pooled plasma from females, collected after a 5 h fast or 5 h fast and OGTT, were separated via FPLC. (e) Plasma TG (purple) and (f) cholesterol (blue) content were measured from the separated lipoproteins. AUC of (e) TG fractions 10–18 of VLDL and (f) cholesterol fractions 30–50 of HDL (TG:10A+/+ n = 6, 10A−/− n = 7, Chol:10A+/+ n = 6, 10A−/− n = 6). P value by unpaired t-test.
