Figure 2 | Scientific Reports

Figure 2

From: Apatinib weakens proliferation, migration, invasion, and angiogenesis of thyroid cancer cells through downregulating pyruvate kinase M2

Figure 2

Apatinib prominently suppressed HUVEC tube formation and weakened PKM2 expression in TC. (A) Images of tube formation assay in HUVECs, which were incubated with the conditioned medium from Apatinib-treated SW579 and TPC-1 cells. Magnification, 100 ×. (B) After incubation with the conditioned medium, IF staining was conducted to assess the expression change of VEGFR2 in HUVECs. Magnification, 200 ×. (C) The expression change of VEGFA was credited through IF staining in HUVECs after treatment with the conditioned medium from Apatinib-processed SW579 and TPC-1 cells. Magnification, 200 ×. (D) Western blot was utilized to analyze the change of VEGFA and PKM2 expressions in SW579 and TPC-1 cells after administration with Apatinib.

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