Figure 1
From: Tuning of liver circadian transcriptome rhythms by thyroid hormone state in male mice
Dose-dependent effects of thyroid hormone (TH) state on systemic energy metabolism. (A–F) Serum levels of T3 and T4, body weight across the experiment, 24-h profiles of locomotor activity, body temperature, and O2 consumption are shown. Rhythmicity was assessed using CircaCompare algorithm. Presence (R) or absence (NR) of significant circadian rhythmicity is depicted. In the presence of significant 24-h rhythmicity, a sine curve was fit to the data. (G–J) 24 h average data for locomotor activity, food intake, body temperature, and O2 consumption for MMI, CON, and T311 groups. One-way ANOVA was performed (p value is shown) followed by Tukey’s post-test comparisons (depicted with asterisks). In (A) and (B), n = 4–6 animals per group or timepoint. In (C), n = 24. In (D), n = 4 and 5 for CON and MMI groups, respectively. In (E) and (F), n = 4 for each group. *, **, ***, **** represent a p value of < 0.05, 0.01, 0.001, and 0.0001, respectively.
