Table 1 Patient and treatment characteristics.

From: Impact of radiation doses on clinical relapse of biochemically recurrent prostate cancer after prostatectomy

Characteristic

All patients

 < 66 Gy group

 ≥ 66 Gy group

p-value

Total

n = 292

n = 66

n = 226

Age at SRT (year)

68 (49–80)

70 (52–77)

68 (49–80)

0.22

Gleason score

   

0.013

 ≤ 6

30 (10%)

11 (17%)

19 (8.4%)

 

7

161 (55%)

41 (62%)

120 (53%)

 

8–10

101 (35%)

14 (21%)

87 (39%)

 

T stage

   

0.68

 ≤ pT2c

159 (55%)

38 (58%)

121 (54%)

 

pT3a

88 (30%)

17 (26%)

71 (31%)

 

pT3b

45 (15%)

11 (17%)

34 (15%)

 

ECE + 

123 (42%)

23 (35%)

100 (44%)

0.20

SVI + 

45 (15%)

11 (17%)

34 (15%)

0.70

Surgical margin + 

172 (59%)

33 (50%)

139 (62%)

0.12

Preoperative initial PSA (ng/ml)

11.4 (4.00–84.1)

10.8 (4.00–56.9)

11.7 (4.18–84.1)

0.59

Postoperative PSA nadir (ng/ml)

0.04 (0.00–1.82)

0.06 (0.00–1.74)

0.04 (0.00–1.82)

0.83

PSA at BCR after RP (ng/ml)

0.38 (0.10–1.94)

0.32 (0.10–1.94)

0.42 (0.10–2.00)

0.012

EQD2 (Gy)

66.0 (61.0–85.0)

64.0 (61.0–65.0)

67.0 (66.0–85.0)

 < 0.001

WPRT

11 (4%)

2 (3%)

9 (4%)

1.0

Short-term ADT use with SRT

16 (6%)

2 (3%)

14 (6%)

0.54

Follow-up time (month)a

73 (5–189)

98 (11–166)

68 (5–189)

0.001

2006–2013

n = 131

n = 54

n = 77

 
 

102 (6–189)

114 (11–166)

100 (6–189)

0.25

2014–2018

n = 161

n = 12

n = 149

 
 

60 (5–97)

55 (23–92)

61 (5–97)

0.42

Total

n = 118

n = 23

n = 95

 

PSA at BCR after SRT (ng/ml)

0.30 (0.01–4.32)

0.35 (0.21–3.21)

0.30 (0.01–4.32)

0.24

ADT use in patients with recurrence after SRT

99 (84%)

21 (91%)

78 (82%)

0.36

  1. Data are n (%) or medians (range).
  2. SRT salvage radiotherapy, ECE extracapsular extension, SVI seminal vesicle involvement, PSA prostate-specific antigen, BCR biochemical recurrence, RP radical prostatectomy, EQD2 equivalent dose in 2-Gy fractions, WPRT whole-pelvic radiotherapy, ADT androgen deprivation therapy.
  3. aThe follow-up time was stratified by the year of the initiation of SRT: 2006–2013 and 2014–2018.