Table 3 Univariate and multivariate analyses of clinical and pathological factors predictive of clinical relapse after salvage radiotherapy.

From: Impact of radiation doses on clinical relapse of biochemically recurrent prostate cancer after prostatectomy

Predictor

Univariate

Multivariate

HR (95% CI)

p-value

HR (95% CI)

p-value

Age at SRT < 70

0.81 (0.35–1.89)

0.63

0.58 (0.23–1.47)

0.25

Gleason score ≥ 8

3.07 (1.30–7.25)

0.01

3.16 (1.25–7.98)

0.015

ECE + 

2.40 (1.00–5.71)

0.049

1.74 (0.64–4.71)

0.28

SVI + 

5.37 (2.31–12.7)

 < 0.001

3.55 (1.33–9.52)

0.012

Surgical margin − 

1.57 (0.68–3.63)

0.29

2.06 (0.83–5.09)

0.12

PSA at BCR after RP ≥ 0.50 ng/ml

2.51 (1.07–5.87)

0.034

2.90 (1.15–7.29)

0.024

EQD2 < 66 Gy

2.61 (1.12–6.12)

0.027

4.31 (1.72–10.81)

0.0018

  1. HR hazard ratio, 95% CI 95% confidence interval, SRT salvage radiotherapy, ECE extracapsular extension, SVI seminal vesicle involvement, PSA prostate-specific antigen, BCR biochemical recurrence, RP radical prostatectomy, EQD2 equivalent dose in 2-Gy fractions.
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