Table 3 Odds ratios of %C3-epi-25(OH)D3 in multiple diseases.

From: C3-epi-25(OH)D3 percentage, not level, may be a potential biomarker to reflect its pathological increase in multiple diseases: a cross-sectional case–control study

Disease

Crude analysis

Adjusted analysis (1) *

Adjusted analysis (2) *

OR (95%CI)

Wald χ2

P

OR (95%CI)

Wald χ2

P

OR (95%CI)

Wald χ2

P

Adverse pregnancy

2.10(1.40, 3.19)

12.558

 < 0.001

1.50(1.35, 1.66)

59.439

 < 0.001

1.50(1.28, 1.77)

24.321

 < 0.001

Abortion

1.66(1.26, 2.19)

12.787

 < 0.001

1.31(1.22, 1.41)

53.074

 < 0.001

1.28(1.14, 1.44)

17.953

 < 0.001

Normal pregnancy

1.21(1.05, 1.40)

6.588

0.010

1.21(1.06, 1.37)

8.529

0.003

1.15(0.98, 1.35)

2.943

0.086

Acyesis

1.42(1.19, 1.70)

15.255

 < 0.001

1.21(1.13, 1.29)

33.957

 < 0.001

1.38(1.24, 1.69)

9.800

0.002

Premature ovarian failure

1.17(1.10, 1.26)

22.006

 < 0.001

1.43(1.22, 1.68)

19.976

 < 0.001

1.11(1.00, 1.22)

3.917

0.050

Uterine fibroids

0.98(0.76, 1.25)

0.040

0.841

0.98(0.77, 1.25)

0.022

0.883

0.90(0.68, 1.18)

0.582

0.445

Hypovitaminosis D

1.23(1.11, 1.36)

16.042

 < 0.001

1.24(1.12, 1.37)

17.774

 < 0.001

1.08(0.97, 1.20)

1.820

0.177

Osteoporosis

1.24(1.19, 1.29)

95.943

 < 0.001

1.23(1.17, 1.28)

81.746

 < 0.001

1.17(1.11, 1.23)

33.192

 < 0.001

Arthritis

1.22(1.18, 1.26)

138.725

 < 0.001

1.20(1.16, 1.24)

109.507

 < 0.001

1.11(1.07, 1.17)

22.783

 < 0.001

Ankylosing Spondylitis

1.04(0.87, 1.23)

0.187

0.665

1.06(0.90, 1.26)

0.521

0.470

0.95(0.79, 1.15)

0.256

0.613

Disk herniation

1.21(1.14, 1.28)

43.108

 < 0.001

1.18(1.11, 1.25)

31.626

 < 0.001

1.10(1.03, 1.17)

8.285

0.004

Myofascitis

1.25(1.11, 1.41)

14.027

 < 0.001

1.22(1.09, 1.35)

12.745

 < 0.001

1.13(0.99, 1.28)

3.456

0.063

Muscle pain

1.24(1.15, 1.34)

30.049

 < 0.001

1.18(1.11, 1.27)

23.235

 < 0.001

1.08(0.98, 1.19)

2.627

0.105

Lumbago

1.17(1.01, 1.35)

4.290

0.038

1.15(1.01, 1.31)

4.311

0.038

1.01(0.86, 1.18)

0.010

0.919

Muscular strain

1.16(1.01, 1.35)

4.132

0.042

1.15(1.01, 1.32)

4.359

0.037

1.03(0.89, 1.20)

0.187

0.666

Pneumonia

1.51(1.21, 1.88)

13.159

 < 0.001

1.30(1.20, 1.41)

43.123

 < 0.001

1.42(1.10, 1.83)

7.122

0.008

Respiratory infection

1.44(1.29, 1.61)

43.956

 < 0.001

1.41(1.23, 1.61)

25.191

 < 0.001

1.13(0.97, 1.31)

2.366

0.124

Bronchitis

1.70(1.39, 2.09)

25.815

 < 0.001

1.35(1.15, 1.57)

14.284

 < 0.001

1.32(0.98, 1.73)

3.075

0.079

Coronary artery disease

1.33(1.17, 1.52)

19.130

 < 0.001

1.27(1.14, 1.42)

18.373

 < 0.001

1.16(0.97, 1.38)

2.759

0.097

Stroke

1.28(1.17, 1.48)

12.276

 < 0.001

1.20(1.05, 1.37)

7.124

0.008

1.03(0.85, 1.24)

0.066

0.797

Thrombosis

1.20(1.08, 1.34)

10.650

0.001

1.25(1.13, 1.38)

18.538

 < 0.001

1.23(1.05, 1.44)

6.743

0.009

Metabolic syndrome

1.18(1.08, 1.29)

13.782

 < 0.001

1.22(1.12, 1.33)

22.506

 < 0.001

1.12(1.01, 1.24)

4.305

0.038

Menopausal syndrome

1.21(1.11, 1.31)

20.357

 < 0.001

1.21(1.12, 1.30)

22.524

 < 0.001

1.14(1.03, 1.27)

6.592

0.010

Hypothyreosis

1.19(1.04, 1.36)

6.547

0.011

1.20(1.06, 1.35)

8.571

0.003

1.13(0.98, 1.30)

2.889

0.089

Hyperthyroidism

1.34(1.16, 1.55)

16.033

 < 0.001

1.33(1.17, 1.52)

18.842

 < 0.001

1.27(1.08, 1.49)

8.297

0.004

Hashimoto thyroiditis

1.12(0.92, 1.36)

1.204

0.272

1.15(0.95, 1.39)

2.045

0.153

1.04(0.85, 1.29)

0.162

0.687

Diabetes mellitus

1.26(1.20, 1.32)

86.669

 < 0.001

1.22(1.16, 1.27)

67.408

 < 0.001

1.11(1.03, 1.19)

7.746

0.005

Sjogren syndrome

1.21(1.11, 1.31)

20.454

 < 0.001

1.19(1.10, 1.29)

19.566

 < 0.001

1.08(0.98, 1.20)

2.330

0.127

Lupus erythematosus

1.37(1.25, 1.50)

48.026

 < 0.001

1.35(1.26, 1.45)

65.990

 < 0.001

1.23(1.11, 1.37)

14.299

 < 0.001

Connective tissue disease

1.23(1.11, 1.37)

15.057

 < 0.001

1.21(1.10, 1.33)

14.579

 < 0.001

1.14(0.99, 1.30)

3.287

0.070

Dermatomyositis

1.50(1.31, 1.71)

35.535

 < 0.001

1.38(1.25, 1.53)

37.816

 < 0.001

1.30(1.13, 1.50)

12.796

 < 0.001

Autiommune hepatitis

1.36(1.18, 1.57)

17.257

 < 0.001

1.30(1.14, 1.47)

16.706

 < 0.001

1.20(1.03, 1.39)

5.566

0.018

  1. The multinomial logistic regression was used. * (1) Adjusted by gender, age, season; (2) Adjusted by gender, age, season and 25(OH)D3 level. An increase in %C3-epi-25(OH)D3 can predict an increased risk of 29/32 (90.6%) specific diseases, regardless of adjusted for gender, age, and season. But adjustment for 25(OH)D3 level significantly reduced the ability of %C3-epi-25(OH)D3 to predict disease risk. Significant values are in bold.
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