Table 2 MICs of different β-lactams against the indicated E. cloacae wildtype strain, spontaneous AmpD-defective mutants and ECL_02804 KO mutants constructed in the laboratory.
From: Filling knowledge gaps related to AmpC-dependent β-lactam resistance in Enterobacter cloacae
Strain | MICs (mg/l) | ampD mutation | ||||||
|---|---|---|---|---|---|---|---|---|
CTX | CAZ | FEP | PIP/TAZ | ATM | TOL/TAZ | CAZ/AVI | ||
ATCC 13047 | 0.38 | 0.38 | 0.032 | 1.5 | 0.5 | 0.38 | 0.19 | NA |
ATCC 13047ΔAD | 32 | 48 | 0.5 | 48 | 12 | 6 | 0.25 | Deletion of nt 432 |
ATCC 13047ΔAD-b | 32 | 64 | 0.5 | 48 | 12 | 6 | 0.25 | Deletion of 4 nts (183–186) |
ATCC 13047ΔAD-c | 32 | 48 | 0.5 | 48 | 12 | 6 | 0.25 | Deletion of nt 279 |
ATCC 13047ΔAD-d | 32 | 48 | 0.5 | 96 | 12 | 4 | 0.25 | Deletion of 2 nts (276–277) |
ATCC 13047ΔAD-e | 48 | 48 | 0.5 | 48 | 24 | 4 | 0.25 | C → T change (nt 385): stop codon |
ATCC 13047 Δ02804 | 0.38 | 0.38 | 0.032 | 1 | 0.25 | 0.5 | 0.19 | NA |
ATCC 13047ΔAD Δ02804 | 32 | 64 | 0.5 | 48 | 12 | 6 | 0.25 | Deletion of nt 432 |
