Table 1 Weights and Echocardiographic parameters in all studied groups.

Groups
Parameters		Group I (control)	Group II (ISO)	Group III (ISO + captopril)	Group IV (ISO + melatonin)	Group V (ISO + melatonin + captopril)
Body weight (g)	Mean ± SD	229.8 ± 10.2	219.1 ± 10.8	228.8 ± 8.6	222.2 ± 10.5	228.1 ± 8.8
	p value		p > 0.05^a	p > 0.05^a,b	p > 0.05^a,b,c	p > 0.05^a,b,c,d
Heart weight (g)	Mean ± SD	1.12 ± 0.09	1.73 ± 0.11	1.43 ± 0.11	1.57 ± 0.08	1.28 ± 0.06
	p value		p < 0.001^a	p < 0.001^a,b	p < 0.001^a,b	p < 0.001^a,b,d
					p < 0.01^c	p < 0.01^c
HWI (mg/g)	Mean ± SD	4.89 ± 0.6	7.9 ± 0.43	6.24 ± 0.37	7.06 ± 0.24	5.61 ± 0.16
	p value		p < 0.001^a	p < 0.001^a,b	p < 0.001^a,b,c	p < 0.001^a,b,c,d
LVEDD (mm)	Mean ± SD	5.33 ± 0.42	8.92 ± 0.63	7.14 ± 0.56	8.04 ± 0.55	6.26 ± 0.53
	p value		p < 0.001^a	p < 0.001^a,b	p < 0.001^a,b,c	p < 0.01^a,b,c,d
LVESD (mm)	Mean ± SD	3.1 ± 0.40	7.03 ± 0.6	5.01 ± 0.56	5.99 ± 0.51	4.11 ± 0.47
	p value		p < 0.001^a	p < 0.001^a,b	p < 0.001^a,b,c	p < 0.001^a,b,c,d
LVFS %	Mean ± SD	42 ± 3.12	21.3 ± 1.33	30 ± 2.44	25.6 ± 1.34	34.4 ± 2.45
	p value		p < 0.001^a	p < 0.001^a,	p < 0.001^a,b,c	p < 0.001^a,b,c,d
LVEF %	Mean ± SD	72.4 ± 3.83	41.3 ± 2.4	55.9 ± 4.06	48.7 ± 2.4	62.4 ± 3.65
	p value		p < 0.001^a	p < 0.001^a,b	p < 0.001^a,b,c	p < 0.001^a,b,c,d

SD (standard deviation), a = versus group I, b = versus group II, c = versus group III; d = versus group IV. (HWI) heart weight index, LVEDD; left ventricular End diastolic dimension, LVESD; left ventricular End systolic dimension, LVFS; left ventricular fractional shortening, LVEF; left ventricular ejection fraction.

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