Figure 1

Age and diagnostic effects in cortical gyrification. (A) Linear fitting with 95% Confidence Interval (CI) for the model variables in each Diagnostic group, Healthy Controls (CTL, in blue, adjusted R² = 0.85, P < 0.0001), Mild Cognitive Impairment (MCI, in yellow, adjusted R² = 0.88, P < 0.0001), and Alzheimer’s Disease (AD, in red, adjusted R² = 0.86, P < 0.0001). As the severity of the disease increases, the linear tendency is downshifted, with smaller linear intercepts (K). (B) K linear tendency across age with 95% CI for the three diagnostics groups: Alzheimer’s Disease (in red, adjusted R² = 0.026, P = 0.21), Mild Cognitive Impairment (in yellow, adjusted R² = 0.044, P = 0.0051), and Healthy Controls (in blue, adjusted R² = 0.097, P < 0.0001).