Figure 2

Optimal cut-point (maximum sensitivity and specificity) for K and Cortical Thickness, including results with removed age effect (“age correction”). The dashed line represents the optimal cut-point to discriminate Alzheimer’s Disease (AD, in red) and Healthy Controls (CTL, in blue), and the dotted line represents the optimal cut-point for Mild Cognitive Impairment (MCI, in yellow) and Healthy Controls. (A) For K, the optimal cut-point for the CTL-AD is -0.54, and for CTL-MCI, -0.53. (B) For \(log_{10}{T}\), the optimal cut-point for CTL-AD = 0.39 mm and CTL-MCI = 0.40 mm. (C) For K, after age correction, the optimal cut-point for CTL-AD = -0.52 and CTL-MCI = -0.51. (D) For \(log_{10}{T}\), after age correction, the optimal cut-point for CTL-AD = 0.43 mm and Healthy Controls-Mild Cognitive Impairment = 0.44 mm.