Figure 2
From: Time of day bias for biological sampling in studies of mammary cancer
(A) Upper; Venn diagrams of overlap and separation between upregulated and downregulated DEGs in the brains of mammary tumor-bearing compared to vehicle-injected mice by time of day, as determined by three separate filtering methods. Lower; Expression heatmaps of all DEGs in tumor-bearing mice comparing dark to light phases. (B) Ratios of DEGs in the brains of mammary tumor-bearing mice compared to vehicle-injected mice by time of day, as determined by three separate filtering methods. Top: upregulated DEGs. Bottom: downregulated DEGs. Colors indicate time of day of differential expression. Numbers to the right are n of DEGs in each category. NB: there are few genes that are differentially expressed in the brains of mammary tumor-bearing mice independent of time of day of sampling (gray).
