Figure 3

Metascape analyses of DEGs in the brains of mammary tumor-bearing mice compared to vehicle-injected mice using a p value cutoff of 0.05. Left column upregulated in tumor-bearing mice; right column downregulated in tumor-bearing mice. (A,B) heatmaps of GO biological processes affected by the DEGs by time of day. GO biological processes in red font are only affected during one time of day. (C,D) circos plot of overlap of individual unique genes by time of day. Outer ring red = dark, blue = light. Inner ring, dark orange represents shared genes across time of day, light orange represents unique genes to each time of day, purple lines connect individual shared genes between lists. Amount of dark red inner arc and number of purple lines indicate overlap between times of day. (E–G) GO biological enrichment networks of DEGs: (E) upregulated in dark, (F) upregulated in light, (G) downregulated in dark, (G) downregulated in light.