Figure 4
The genes encoding the components of the RQC complex are not essential. (A) Scores attributed to the impact of gene inactivation on the growth rate in 1086 cancer cell lines for LTN1, NEMF, and TCF25. Data obtained from Tsherniak et al.56. (B) Correlation graph of the silencing effect between NEMF and LTN1. (C) Word cloud representation of the cellular lineages more affected by NEMF and LTN1 silencing. (D) Haploinsufficiency scores for each component of the RQC complex and ZNF598. Genes with values equal to or greater than 0.86 are considered haploinsufficient. Data obtained from Collins et al.57.
