Figure 5 | Scientific Reports

Figure 5

From: Transcriptional profile of ribosome-associated quality control components and their associated phenotypes in mammalian cells

Figure 5

Transcriptional regulation elicited by RQC knockdown in human cells. (A) Heatmap of the Z-score distribution of the transcriptional profile when RQC genes were downregulated by CRISPR interference (CRISPRi) in the leukemia K562 cell line. Data obtained from Replogle et al.58. (B) Ontology enrichment of genes that showed the greatest similarity in their expression profiles when we silenced LTN1 and NEMF, as shown in Panel A. The results for up- and downregulated gene clusters are shown in red and green, respectively.

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