Table 1 Example question and response from ChatGPT-4.

Question: ‘’I am 23 years old and 5 weeks pregnant. In my thyroid function tests, TSH level was 5.4 mIU/L and my free T4 level was within the normal reference range. My thyroid antibody is positive. Should I take levothyroxine?’’

ChatGPT-4 response: ‘’The decision to treat subclinical hypothyroidism (characterized by a high thyroid-stimulating hormone [TSH] level but normal free thyroxine [FT4] levels) with levothyroxine during pregnancy is often made on a case-by-case basis. Your TSH level of 5.4 mIU/L is higher than the upper limit of the typical recommended range for the first trimester (which is generally about 2.5 mIU/L according to the American Thyroid Association), and you also have positive thyroid antibodies, which is associated with an increased risk of pregnancy complications. Some clinical guidelines suggest considering treatment with levothyroxine in this situation, as it may help reduce the risk of complications. However, this is a decision that needs to be made in discussion with your healthcare provider, taking into account your individual circumstances and the potential risks and benefits of treatment. In addition, even if you do not start treatment, it’s important to have your thyroid function closely monitored throughout your pregnancy. Thyroid requirements can change over the course of pregnancy, and it’s possible that you might need treatment later on. Please make sure to discuss this with your healthcare provider, who can provide the most accurate advice based on your individual situation. The information provided here should be used as a guide and does not replace professional medical advice.’’