Table 1 Patients’ backgrounds.

From: Comparative analysis of hyperfibrinolysis with activated coagulation between amniotic fluid embolism and severe placental abruption

Group

Control

AFE (n = 27)

sPA (n = 12)

P value

Before labor (n = 9)

During labor (n = 7)

Postpartum (n = 7)

Age (year)

33

[28–45]

28

[18–38]

27

[23–32]

35

[25–43]

34

[21–42]

< 0.01a

Primipara (case)

2

(22.2%)

3

(42.9%)

3

(42.9%)

7

(25.9%)

6

(50.0%)

0.52

Preeclampsia (case)

0

(0%)

0

(0%)

0

(0%)

0

(0%)

1

(8.3%)

0.38

Gestational age at delivery (day)

267

[255–281]

277

[261–287]

277

[267–282]

274

[179–292]

242

[191–271]

< 0.01b

Mode of delivery (case)

 Vaginal

2

(22.2%)

7

(100%)

6

(85.7%)

15

(55.6%)

2

(16.7%)

< 0.001c

 Cesarean

7

(77.8%)

0

(0%)

1

(14.3%)

12

(44.4%)

10

(83.3%)

 

Onset (case)

 Before labor

NA

 

NA

 

NA

 

3

(11.1%)

12

(100%)

 < 0.01d

 During labor

NA

 

NA

 

NA

 

8

(29.6%)

0

(0%)

 

 Postpartum

NA

 

NA

 

NA

 

16

(59.3%)

0

(0%)

 

Gestational period at the onsete

 Before labor, gestational age (day)

267

[255–281]

NA

 

 NA

 

231

[203–288]

242

[191–271]

< 0.05f

 During labor, gestational age (day)

NA

 

277

[261–287]

NA

 

278

[179–292]

NA

 

0.63

 Postpartum, time after delivery (min)

NA

 

NA

 

1086

[484–1697]

60

[0–240]

NA

 

< 0.0001

Clinical symptoms (case)

 Cardiac arrest

NA

 

NA

 

NA

 

9

(33.3%)

0

(0%)

< 0.05

 Respiratory failure

NA

 

NA

 

NA

 

4

(14.8%)

0

(0%)

0.29

 PPH

NA

 

NA

 

NA

 

23

(85.2%)

9

(75.0%)

0.65

 NRFS

NA

 

NA

 

NA

 

14

(51.9%)

8

(66.7%)

0.49

 IUFD

NA

 

NA

 

NA

 

2

(7.4%)

4

(33.3%)

0.06

Time of the onset to blood collection (min)

NA

 

NA

 

NA

 

60

[0–200]

105

[0–360]

0.21

Blood loss at blood collection (mL)

0

[0–0]

0

[0–0]

350

[180–965]

4900

[880–7000]

2648

[430–5140]

< 0.0001g

Fluid amount at blood collection (mL)

0

[0–0]

0

[0–0]

600

[600–1300]

1300

[0–5500]

1355

[0–6000]

< 0.0001h

Maternal death (case)

NA

 

NA

 

NA

 

4

(14.8%)

0

(0%)

0.29

Neonatal death (case)

NA

 

NA

 

NA

 

2

(7.4%)

5

(41.7%)

< 0.05

  1. Continuous data are shown as medians with minimum to maximum. Categorical data are represented as numbers with percentages. aPost hoc multiple comparisons showed a significant difference between Postpartum in the control and AFE groups (P < 0.01). bPost hoc multiple comparisons showed significant differences between During labor in the control and sPA groups (P < 0.05), Postpartum in the control and sPA groups (P < 0.05), as well as the AFE and sPA groups (P < 0.01). cResidual analysis showed that During labor in the control group had significantly more vaginal deliveries (P < 0.01) and that the sPA group had significantly more Cesarean deliveries (P < 0.01). dResidual analysis showed that the sPA group had significantly more cases of Before labor (P < 0.01) and that the AFE group had significantly more patients of During labor (P < 0.05) and Postpartum (P < 0.01). eThe gestational age or time after delivery at blood collection was described in the control group. fPost hoc multiple comparisons showed a significant difference between Before labor in the control and sPA groups (P < 0.05). gPost hoc multiple comparisons showed significant differences between Before labor in the control and AFE groups (P < 0.0001), Before labor in the control and sPA groups (P < 0.01), During labor in the control and AFE groups (P < 0.0001), During labor in the control and sPA groups (P < 0.01), as well as Postpartum in the control and the AFE groups (P < 0.05). hPost hoc multiple comparisons showed significant differences between Before labor in the control and AFE groups (P < 0.001), Before labor in the control and sPA groups (P < 0.001), During labor in the control and AFE groups (P < 0.01), as well as During labor in the control and sPA groups (P < 0.01). AFE amniotic fluid embolism, sPA severe placental abruption, NA not applicable, min minute, PPH postpartum hemorrhage, NRFS non-reassuring fetal status, IUFD intrauterine fetal death.
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