Table 2 Multivariable Cox regression for mortality by total cholesterol, LDL-C, HDL-C, and TG.

From: Association between total cholesterol levels and all-cause mortality among newly diagnosed patients with cancer

 

No. of patients

Events

Person-years

Incidence rate (per 10,000 py)

Age and sex adjusted hazard ratio (95%CI)

Multivariable-adjusted hazard ratio (95%CI)

HR (95%CI)

Association between TC at cancer diagnosis and the risk of all-cause death by centile groups

 1st–5th (≤ 97 mg/dL)

3012

1143

15,924

717.8

1.79 (1.66–1.93)

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1.54 (1.43–1.66)

 6th–20th (97–128 mg/dL)

9217

2711

52,843

513.0

1.46 (1.38–1.55)

1.26 (1.19–1.34)

 21st–40th (129–151 mg/dL)

12,006

2756

72,626

379.5

1.20 (1.13–1.27)

1.09 (1.03–1.16)

 41st–60th (152–171 mg/dL)

11,467

2222

70,407

315.6

1.09 (1.03–1.16)

1.03 (0.97–1.09)

 61st–80th (172–196 mg/dL)

11,903

1310

54,828

238.9

Reference

Reference

 81st–95th (197–233 mg/dL)

8690

1970

74,323

265.1

0.96 (0.89–1.03)

1.02 (0.95–1.09)

 96th–100th (> 233 mg/dL)

2922

512

18,428

277.8

1.20 (1.09–1.33)

1.28 (1.16–1.41)

Association between LDL-C at cancer diagnosis and the risk of all-cause death by centile groups

 1st–5th (≤ 57 mg/dL)

646

197

2,579

76.4

2.10 (1.74–2.54)

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1.38 (1.14–1.68)

 6th–20th (57–79 mg/dL)

1811

365

8,374

43.6

1.56 (1.33–1.83)

1.19 (1.01–1.40)

 21st–40th (79–97 mg/dL)

2427

344

12,306

28.0

1.17 (1.00–1.38)

1.02 (0.87–1.20)

 41st–60th (97–115 mg/dL)

2548

296

13,110

22.6

1.09 (0.92–1.28)

1.08 (0.91–1.28)

 61st–80th (115–136 mg/dL)

2368

252

12,546

20.1

Reference

Reference

 81st–95th (136–167 mg/dL)

1786

160

9,560

16.7

0.89 (0.73–1.08)

0.95 (0.78–1.16)

 96th–100th (> 167 mg/dL)

598

48

3,142

15.3

0.89 (0.65–1.22)

0.94 (0.69–1.28)

Association between HDL-C at cancer diagnosis and the risk of all-cause death by quartile groups

 Q1 (≤ 40 mg/dL)

3270

772

14,593

529

2.65 (2.24–3.14)

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2.10 (1.77–2.50)

 Q2 (40–50 mg/dL)

3097

445

15,895

280

1.72 (1.44–2.05)

1.66 (1.39–1.98)

 Q3 (50–61 mg/dL)

2798

266

15,087

176.3

1.24 (1.03–1.50)

1.27 (1.05–1.54)

 Q4 (> 61 mg/dL)

3022

179

16,054

111.5

Reference

Reference

Association between TG at cancer diagnosis and the risk of all-cause death by quartile groups

 Q1 (≤ 73 mg/dL)

3499

487

18,784

259.3

1.02 (0.90–1.15)

View full size image

0.96 (0.84–1.09)

 Q2 (73–99 mg/dL)

3413

520

16,961

306.6

1.02 (0.90–1.15)

0.95 (0.83–1.07)

 Q3 (99–138 mg/dL)

3440

524

17,286

303.1

1.00 (0.88–1.13)

0.93 (0.82–1.06)

 Q4 (> 138 mg/dL)

3381

500

17,871

279.8

Reference

Reference

  1. Multivariable-adjusted model was adjusted for age, sex, BMI, use of lipid-lowering agents, presence of CKD, DM, and HTN, smoking status, alcohol consumption, and cancer type.
  2. CKD chronic kidney disease, DM diabetes mellitus, HDL-C high-density lipoprotein cholesterol, HR hazard ratio, HTN hypertension, LDL-C low-density lipoprotein cholesterol, TG triglyceride, TC total cholesterol, CI confidence interval.
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