Table 1 Summary of reports for using amniotic membrane transplantation in fungal keratitis.
Study | Description | Epithelial healing rate | The necessity of therapeutic penetrating keratoplasty (TPK) | Persistence of infection | Visual acuity | Complications |
|---|---|---|---|---|---|---|
Chen et al.22 | • 23 eyes of 23 patients (69.6%: active phase, 30.4%: non-active) • Follow up: (6–65) months • Single-layer AMT: 17 cases • Double-layer AMT: 6 cases (perforated), both with epithelial side. up | Complete healing in 12 cases (75%) of the active group and seven patients (100%) in the inactive group | Four patients (25%) in the active group | Two patients (from those who underwent TPK) | The final BCVA improved in 17 cases, worsened in 2 patients, and remained unchanged in 4 cases | AM melt in 3 cases |
Qing et al.23 | • 210 eyes of 210 patients (Group1 (109 eyes): AMG + antifungal + debridement) versus group 2 (101 eyes): debridement + antifungal) | The therapeutic course was (22.4 ± 1.8) days in group 1, significantly shorter than in group 2 (33.2 ± 2.4) | Postoperative visual acuity was better in group 1 | |||
Zeng et al.24 | • 20 eyes of 20 patients (group 1: AMG + antifungal + debridement, 10 eyes) versus group 2: debridement + antifungal; 10 eyes) | The average healing time of the AM group was 6.89 ± 2.98 days, which was shorter than that of the other group (10.23 ± 2.78 days) | 1 case from group 1 Vs. 2 in group 2 needed TPK | The average UCVA of the AM group was 0.138 ± 0.083, which was statistically better than that of the other group (0.053 ± 0.068) | ||
Kim et al.25 | • Case series: 21 eyes of 21 patients with infective keratitis (2 cases FK) • Follow-up (4–28) months | Complete healing in + /− 10 days | 1 case performed PKP | It improved post-op BCVA in the 2 cases One case improved from LP to 14/20 after performing PK | ||
Qiong et al.26 | • 41 eyes of 41 patients with culture-proven fusarium keratitis • All cases: focal keratectomy + AMT • Group 1, 22 eyes (+ cryotherapy) versus group 2, 19 eyes (no cryotherapy) • Follow up (3–12) months | Faster healing in group 1 | ||||
Abdulhalim et al.27 | • 40 eyes of 40 patients (12 eyes with fungal keratitis received conjunctival flap versus 13 with fungal keratitis received AMT) • Follow up: 6 months | No significant differences between the two groups | No significant differences between the two groups | |||
Eleiwa et al.28 | • Case series: 5 patients with post-LASIK fungal keratitis • (They underwent intrastromal injection of Amphotericin B, LASIK flap amputation, and AMT) • Follow-up: 12–18 months | 26 ± 1.8 (median, 27; range, 22–32) days | All cases had elective PKP done 2.4 (median, 2; range, 2–3) months after AMT | The final BCVA ranged from 20/20 to 20/80 at an average follow-up of (median, 14; range, 12–18) months |
