Figure 4 | Scientific Reports

Figure 4

From: Multivalent next generation influenza virus vaccines protect against seasonal and pre-pandemic viruses

Figure 4

Neutralizing antibody titers for seasonal influenza viruses after vaccination in mice. Immunologically naïve DBA/2J mice were vaccinated intramuscularly (i.m.) three times at four-week intervals with quadrivalent (green line) or heptavalent (blue line) formulations of COBRA recombinant HA and NA proteins, with AddaVax™ as adjuvant. Sera collected two weeks after final vaccination were pooled for FRA against modern strains of (a, b) H1N1 and (c, d) H3N2 viruses. Top dashed line represents 50% neutralization, bottom dashed line represents 80% neutralization.

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