Table 4 List of MHC-II epitope candidates and alleles to design a vaccine candidate.

From: Development and immunological evaluation of an mRNA-based vaccine targeting Naegleria fowleri for the treatment of primary amoebic meningoencephalitis

Protein no.

Epitope

Antigenicity

Allergenicity

Alleles

1

EEKKKVQQNPSTTSS

0.8516

Non-allergen

HLA-DPA1*01:03, HLA-DPA1*02:01, HLA-DPA1*02:01, HLA-DPA1*01:03, HLA-DPA1*03:01, HLA-DRB1*15:01, HLA-DRB5*01:01,

AFTMYWDDKFKPLAM

1.1464

Non-allergen

HLA-DPA1*03:01, HLA-DPA1*02:01, HLA-DPA1*01:03, HLA-DPA1*01:03, HLA-DPA1*01:03, HLA-DRB1*07:01, HLA-DPA1*02:01, HLA-DPA1*02:01, HLA-DRB1*09:01, HLA-DRB1*15:01, HLA-DRB1*13:02, HLA-DRB1*04:05, HLA-DRB3*02:02, HLA-DRB1*12:01, HLA-DRB4*01:01, HLA-DQA1*01:02, HLA-DRB1*01:01, HLA-DRB1*08:02, HLA-DQA1*05:01, HLA-DRB1*11:01, HLA-DRB5*01:01,

2

AIFSVYIQGNLQIGA

1.5081

Non-allergen

HLA-DRB1*15:01, HLA-DRB1*13:02, HLA-DRB4*01:01, HLA-DRB1*12:01, HLA-DRB1*04:05, HLA-DRB1*04:01, HLA-DQA1*01:02,

MCVLLGPTAWLILST

0.8646

Non-allergen

HLA-DPA1*01:03, HLA-DPA1*01:03, HLA-DPA1*03, HLA-DRB1*07:01, HLA-DRB1*09:01, HLA-DPA1*02:01, HLA-DRB1*15:01, HLA-DRB1*01:01

3

FTMYWDDKFKPLAMA

1.2667

Non-allergen

HLA-DPA1*01:03, HLA-DQA1*01:01, HLA-DQA1*05:01, HLA-DRB1*03:01, HLA-DPA1*01:03, HLA-DPA1*03:01, HLA-DRB3*01:01,

EENEFFAIETFGSTG

0.6557

Non-allergen

HLA-DRB1*04:01, HLA-DPA1*01:03, HLA-DPA1*02:01, HLA-DRB1*04:05, HLA-DPA1*03:01, HLA-DRB1*08:02, HLA-DQA1*01:0, HLA-DPA1*02:01, HLA-DRB1*09:01, HHLA-DQA1*01:02, LA-DRB1*01:01, HLA-DQA1*05:01, HLA-DRB1*11:01, HLA-DRB1*07:01HLA-DRB5*01:01, HLA-DRB1*15:01

4

FEKKKNIALLVKAFA

0.7803

Non-allergen

HLA-DPA1*02:01, HLA-DPA1*02:01, HLA-DRB1*12:01, HLA-DRB3*02:02, HLA-DRB1*13:02, HLA-DRB1*11:01, HLA-DRB1*08, HLA-DQA1*01:02, HLA-DRB4*01:01, HLA-DPA1*03:01, HLA-DPA1*02:01, HLA-DRB5*01:01, HLA-DRB1*15:01, HLA-DPA1*01:03, HLA-DRB1*01:01, HLA-DRB1*07:01, HLA-DRB1*09:01,

NSDFTKQIFYESFKR

0.9513

Non-allergen

HLA-DPA1*01:03, HLA-DPA1*02:01, HLA-DPA1*02:01, HLA-DPA1*01:03, HLA-DPA1*03:01, HLA-DRB1*15:01, HLA-DRB5*01:01,

5

ILYNRIFQATVLTML

0.9554

Non-allergen

HLA-DPA1*03:01, HLA-DPA1*02:01, HLA-DPA1*01:03, HLA-DPA1*01:03, HLA-DPA1*01:03, HLA-DRB1*07:01, HLA-DPA1*02:01, HLA-DPA1*02:01, HLA-DRB1*09:01, HLA-DRB1*15:01, HLA-DRB1*13:02, HLA-DRB1*04:05, HLA-DRB3*02:02, HLA-DRB1*12:01, HLA-DRB4*01:01, HLA-DQA1*01:02, HLA-DRB1*01:01, HLA-DRB1*08:02, HLA-DQA1*05:01, HLA-DRB1*11:01, HLA-DRB5*01:01,

PYLIVATKTDLLVDG

1.2209

Non-allergen

HLA-DRB1*04:05, HLA-DRB4*01:01, HLA-DRB1*07:01, HLA-DRB1*04:01, HLA-DRB1*13:02, HLA-DRB1*03:01, HLA-DRB1*12:01, HLA-DRB1*08:02, HLA-DRB1*09:01, HLA-DRB3*01:01, HLA-DRB1*15:01, HLA-DRB1*01:01, HLA-DRB1*11:01, HLA-DRB5*01:01,

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