Figure 3 | Scientific Reports

Figure 3

From: Hsa_circ_0081065 exacerbates IH-induced EndMT via regulating miR-665/HIF-1α signal axis and HIF-1α nuclear translocation

Figure 3The alternative text for this image may have been generated using AI.

hsa_circ_0081065 participates in EndMT. (A) RT-qPCR was used to detect the expression of hsa_circ_0081065 with SiRNAs of hsa_circ_0081065 was transfected into HUVEC cells; *P < 0.05, ***P < 0.001; ****P < 0.0001 Vs Si-NC group; (B) EndMT status of HUVECs with intermittent hypoxia, the morphology of endothelial cells transformed from cobblestone like to spindle like characteristic of mesenchymal cells after treating with intermittent hypoxia; (C) The vascular endothelial marker CD31, cell surface protein E-cadherin, mesenchymal cell marker FSP1 and α-SMA was detected by western blot; (D) The expression of Collagen I and Collagen III was detected by western blot treatment with intermittent hypoxia; **P < 0.01, ***P < 0.001; ****P < 0.0001.

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