Table 1 Associations of circulating micronutrients with risk of NAFLD by meta-analysis of discovery and replication datasets.
From: Genetically determined circulating micronutrients and the risk of nonalcoholic fatty liver disease
Nutrients | Inverse-variance weighted | P valuea | P FDR value | MR-Egger | Weighted median | Simple median | Maximum-likelihood method | MR-PRESSO |
|---|---|---|---|---|---|---|---|---|
OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | |||
Beta-Carotene | 0.81 (0.66, 0.99) | 0.047 | 0.164 | 0.88 (0.54, 1.43) | 0.82 (0.68, 0.98) | 0.71 (0.47, 1.07) | 0.81 (0.67, 0.99) | – |
Calcium | 1.17 (0.83, 1.66) | 0.385 | 0.770 | 1.02 (0.50, 2.07) | 1.09 (0.84, 1.42) | 1.08 (0.76, 1.53) | 1.17 (0.82, 1.67) | 1.16 (0.82, 1.63) |
Copper | 1.01 (0.93, 1.10) | 0.835 | 0.927 | – | – | – | 1.04 (0.83, 1.30) | – |
Folate | 0.94 (0.60, 1.47) | 0.778 | 0.927 | – | – | – | 1.15 (0.90, 1.48) | – |
Iron | 1.16 (1.05, 1.29) | 0.006 | 0.028 | 1.28 (1.00, 1.63) | 1.18 (1.03, 1.35) | 1.27 (1.07, 1.51) | 1.20 (1.06, 1.35) | 1.24 (1.11, 1.39) |
Magnesium | 1.09 (0.18, 6.71) | 0.927 | 0.927 | 1.17 (0.60, 2.31) | 1.07 (0.87, 1.32) | 1.06 (0.83, 1.37) | 1.20 (1.06, 1.35) | 1.22 (0.19, 7.77) |
Phosphorus | 0.90 (0.55, 1.47) | 0.676 | 0.927 | 0.98 (0.56, 1.69) | 0.96 (0.54, 1.69) | 0.96 (0.54, 1.69) | 0.90 (0.55, 1.48) | 0.96 (0.79, 1.17) |
Selenium | 1.11 (1.03, 1.20) | 0.005 | 0.028 | 0.81 (0.52,1.25) | 1.12 (1.03, 1.21) | 1.18 (1.05, 1.32) | 1.12 (1.03, 1.21) | 1.11 (1.04, 1.20) |
Vitamin B6 | 1.00 (0.98, 1.02) | 0.868 | 0.927 | – | – | – | – | – |
Vitamin B12 | 1.07(1.03, 1.13) | 0.002 | 0.028 | 1.10 (0.94, 1.28) | 1.07 (0.99, 1.14) | 1.07 (0.94, 1.21) | 1.08 (1.02, 1.13) | 1.07 (1.03, 1.12) |
Vitamin C | 0.96 (0.82, 1.14) | 0.661 | 0.927 | 0.93 (0.70, 1.23) | 0.94 (0.76, 1.15) | 1.05 (0.82, 1.34) | 0.97 (0.82, 1.16) | 1.00 (0.87, 1.14) |
Vitamin D | 0.96 (0.83, 1.12) | 0.635 | 0.927 | 1.03 (0.82, 1.29) | 0.98 (0.83, 1.15) | 0.99 (0.86, 1.15) | 0.96 (0.82, 1.13) | 0.96 (0.90, 1.02) |
Vitamin K1 | 0.93 (0.85, 1.02) | 0.126 | 0.353 | 0.84 (0.65, 1.09) | 0.94 (0.84, 1.05) | 0.97 (0.86, 1.10) | 0.93 (0.84, 1.02) | – |
Zinc | 0.95 (0.87, 1.03) | 0.185 | 0.432 | – | – | – | 0.95 (0.87, 1.02) | – |
