Table 3 Multivariate COX regression of independent prognostic factors for MpBC.

From: Chemotherapy is of prognostic significance to metaplastic breast cancer

 

BCSS

OS

Univariate regression

Multivariate regression

Univariate regression

Multivariate regression

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

Year of diagnosis

0.956 (0.902–1.013)

0.125

  

0.965 (0.917–1.015)

0.166

  

Age

  > 60y

Ref.

 

Ref.

 

Ref.

 

Ref.

 

  ≤ 60y

0.748 (0.579–0.966)

0.026

0.762 (0.577–1.005)

0.054

0.527 (0.419–0.664)

 < 0.001

0.606 (0.472–0.777)

 < 0.001

Race

 

0.716

   

0.716

  

 White

Ref.

0.495

  

Ref.

   

 Black

1.221 (0.875–1.704)

0.239

  

1.123 (0.836–1.507)

0.441

  

 Others*

1.079 (0.664–1.751)

0.760

  

0.961 (0.621–1.487)

0.858

  

Grade

 

0.013

 

0.165

 

0.009

 

0.048

 III

Ref.

 

Ref.

 

Ref.

 

Ref.

 

 I

0.453 (0.201–1.019)

0.056

0.848 (0.368–1.953)

0.699

0.451 (0.223–0.910)

0.026

0.634 (0.308–1.306)

0.217

 II

0.587 (0.375–0.919)

0.020

0.645 (0.409–1.019)

0.060

0.656 (0.453–0.950)

0.026

0.651 (0.446–0.951)

0.026

Stage

 

 < 0.001

 

 < 0.001

 

 < 0.001

 

 < 0.001

 IIIC

Ref.

 

Ref.

 

Ref.

 

Ref.

 

 I

0.082 (0.036–0.189)

 < 0.001

0.099 (0.042–0.234)

 < 0.001

0.098 (0.051–0.190)

 < 0.001

0.113 (0.057–0.224)

 < 0.001

 IIA

0.249 (0.121–0.515)

 < 0.001

0.271 (0.128–0.571)

0.001

0.220 (0.121–0.398)

 < 0.001

0.239 (0.129–0.441)

 < 0.001

 IIB

0.502 (0.240–1.047)

0.066

0.537 (0.255–1.134)

0.103

0.427 (0.233–0.783)

0.006

0.469 (0.253–0.868)

0.016

 IIIA

0.816 (0.376–1.770)

0.606

0.921 (0.421–2.016)

0.837

0.583 (0.303–1.123)

0.107

0.736 (0.378–1.431)

0.366

 IIIB

1.024 (0.472–2.223)

0.951

0.950 (0.433–2.084)

0.899

0.812 (0.424–1.553)

0.529

0.756 (0.391–1.462)

0.406

Subtype

 

0.864

   

0.626

  

 TNBC

Ref.

   

Ref.

   

 HR–/HER2 + 

0.779 (0.384–1.583)

0.491

  

0.704 (0.374–1.327)

0.278

  

 HR + /HER2 + 

1.130 (0.464–2.748)

0.788

  

0.825 (0.340–2.000)

0.670

  

 HR + /HER2–

0.930 (0.683–1.265)

0.642

  

0.900 (0.690–1.176)

0.441

  

Surgery

 BCS

Ref.

 

Ref.

 

Ref.

 

Ref.

 

 Mastectomy

2.452 (1.847–3.257)

 < 0.001

1.369 (1.001–1.872)

0.049

2.112 (1.666–2.676)

 < 0.001

1.244 (0.956–1.619)

0.105

Radiation therapy

 No or unknown

Ref.

 

Ref.

 

Ref.

 

Ref.

 

 Yes

0.771 (0.598–0.995)

0.046

0.756 (0.566–1.010)

0.058

0.694 (0.556–0.865)

0.001

0.765 (0.596–0.983)

0.036

Chemotherapy

 

 < 0.001

 

0.009

 

 < 0.001

 

 < 0.001

 No CT

Ref.

 

Ref.

 

Ref.

 

Ref.

 

 NAC- non response

2.502 (1.533–4.081)

 < 0.001

1.266 (0.744–2.155)

0.384

1.691 (1.088–2.628)

0.019

0.984 (0.610–1.587)

0.947

 NAC- response

1.039 (0.700–1.544)

0.849

0.691 (0.444–1.077)

0.102

0.632 (0.440–0.907)

0.013

0.479 (0.321–0.715)

 < 0.001

 Adjuvant CT

0.618 (0.462–0.827)

0.001

0.658 (0.480–0.902)

0.009

0.401 (0.314–0.512)

 < 0.001

0.451 (0.346–0.587)

 < 0.001

  1. *American Indian/AK native, Ascian/Pacific Islander.
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