Table 5 Multivariate COX regression of independent prognostic factors of MpBC-TNBC and IDC-TNBC.

From: Chemotherapy is of prognostic significance to metaplastic breast cancer

 

BCSS

OS

Univariate regression

Multivariate regression

Univariate regression

Multivariate regression

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

Histology

 IDC-TNBC

Ref.

 

Ref.

 

Ref.

 

Ref.

 

 MpBC-TNBC

1.227 (1.036–1.453)

0.018

1.239 (1.046–1.468)

0.013

1.245 (1.077–1.440)

0.003

1.277 (1.104–1.477)

0.001

Year of diagnosis

1.030 (0.999–1.063)

0.058

  

1.029 (1.002–1.057)

0.037

1.045 (1.017–1.075)

0.001

Age

  > 60y

Ref.

   

Ref.

   

  ≤ 60y

0.970 (0.842–1.118)

0.678

  

0.840 (0.743–0.951)

0.006

0.914 (0.800–1.044)

0.183

Race

 

0.388

   

0.124

  

 White

Ref.

   

Ref.

   

 Black

1.125 (0.931–1.359)

0.223

  

1.124 (0.955–1.322)

0.160

  

 Others*

0.926 (0.684–1.253)

0.618

  

0.832 (0.633–1.093)

0.185

  

Stage

 

 < 0.001

 

 < 0.001

 

 < 0.001

 

 < 0.001

 IIIC

Ref.

 

Ref.

 

Ref.

 

Ref.

 

 I

0.086 (0.055–0.136)

 < 0.001

0.102 (0.064–0.163)

 < 0.001

0.119 (0.080–0.176)

 < 0.001

0.131 (0.087–0.195)

 < 0.001

 IIA

0.188 (0.124–0.286)

 < 0.001

0.217 (0.142–0.332)

 < 0.001

0.212 (0.146–0.307)

 < 0.001

0.228 (0.156–0.333)

 < 0.001

 IIB

0.422 (0.277–0.643)

 < 0.001

0.458 (0.299–0.702)

 < 0.001

0.405 (0.278–0.592)

 < 0.001

0.431 (0.294–0.631)

 < 0.001

 IIIA

0.507 (0.316–0.815)

0.005

0.553 (0.342–0.894)

0.016

0.477 (0.311–0.732)

0.001

0.510 (0.331–0.788)

0.002

 IIIB

0.902 (0.580–1.403)

0.648

0.885 (0.568–1.380)

0.590

0.797 (0.534–1.190)

0.267

0.767 (0.512–1.147)

0.196

Surgery

 BCS

Ref.

 

Ref.

 

Ref.

 

Ref.

 

 Mastectomy

2.094 (1.801–2.434)

 < 0.001

1.333 (1.136–1.564)

 < 0.001

1.815 (1.599–2.060)

 < 0.001

1.268 (1.108–1.451)

0.001

Radiation therapy

 No or unknown

Ref.

   

Ref.

   

 Yes

0.979 (0.851–1.127)

0.772

  

0.895 (0.793–1.010)

0.073

  

Chemotherapy

 

 < 0.001

 

 < 0.001

 

 < 0.001

 

 < 0.001

 No CT

Ref.

 

Ref.

 

Ref.

 

Ref.

 

 NAC- non response

1.799 (1.277–2.535)

0.001

0.801 (0.564–1.139)

0.217

1.400 (1.015–1.931)

0.040

0.683 (0.488–0.956)

0.026

 NAC- response

1.336 (1.070–1.668)

0.011

0.841 (0.668–1.059)

0.141

1.120 (0.918–1.365)

0.264

0.759 (0.611–0.942)

0.012

 Adjuvant CT

0.686 (0.587–0.803)

 < 0.001

0.702 (0.598–0.823)

 < 0.001

0.634 (0.556–0.725)

 < 0.001

0.656 (0.570–0.755)

 < 0.001

  1. *American Indian/AK native, Ascian/Pacific Islander.
Back to article page