Figure 4

Images of the right eye of an 87-year-old man with polypoidal choroidal vasculopathy in the group with disappearance of blood flow signals within polypoidal lesions. (a–f): Baseline. Best corrected-visual acuity (BCVA) of the right eye is 0.16 logarithm of the minimal angle of resolution (logMAR) units. (a) Color fundus photograph shows a protruding lesion with serous retinal detachment (SRD) and hard exudates superotemporal to the optic disk. (b) Indocyanine green angiography (ICGA) shows a polypoidal lesion with a branching neovascular network (BVN). (c) Optical coherence tomography (OCT) B-scan image through the polypoidal lesion shows a sharp-peaked pigment epithelial detachment (PED) with SRD. (d) OCT angiography (OCTA) en face image shows blood flow signals corresponding to the polypoidal lesion and the BVN. (e, f) OCTA B-scan images (e: horizontal, f: vertical) show blood flow signal in the sub-RPE ring-like structure corresponding to the polypoidal lesion (arrowheads). (g–l) 3 months after the initial treatment. BCVA of the right eye is − 0.08 logMAR units. (g) Color fundus photograph shows no SRD. (h) ICGA shows complete regression of the polypoidal lesion. (i) OCT B-scan image shows the sharp-peaked PED to be diminished without SRD. (j) OCTA en face image shows no blood flow signal corresponding to the polypoidal lesion and the BVN. (k, l) OCTA B-scan images (k: horizontal, l: vertical) show no blood flow signal at the edge of the PED, which had been detected at baseline. (m–p) One year after the initial treatment. BCVA of the right eye is − 0.08 logMAR units. In total, 6 injections were given during the 1-year study period. (m) Color fundus photograph shows no exudative changes. (n–p) OCT B-scans through the fovea (n: horizontal, o: vertical, p: radial through the regressed polypoidal lesion) show dry macula.