Table 2 Risk of ischemic stroke associated with concomitant use of clopidogrel and omeprazole and co-prescription of clopidogrel and pantoprazole.

From: Effects of treatment with clopidogrel with or without proton pump inhibitor omeprazole on the risk of ischemic stroke: a nationwide cohort study

Variable

No. of patients

No. of PYs

No. of ischemic stroke

Incidence rate (per 1000 PYs)

Adjusted HR (95% CI)

Clopidogrel alone

814

6370.28

366

57.45

1.00 (reference)

Clopidogrel + omeprazole

407

2779.59

227

81.67

1.65 (1.12–2.86)

Clopidogrel + pantoprazole

230

1737.61

106

61.00

1.13 (0.81–3.53)

  1. PYs, person-years; HR, hazard ratio; CI, confidence interval.
  2. Hazard ratios were adjusted for age, sex, comorbidities, including hypertension, diabetes mellitus, hyperlipidemia, chronic obstructive pulmonary disease, tobacco dependence, alcohol-related disorders, as well as use of co-medications, including anti-hypertensive drugs, hypoglycemic agents, statins, and low-dose aspirins.
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