Figure 2 | Scientific Reports

Figure 2

From: Investigation, scaffold hopping of novel donepezil-based compounds as anti-Alzhiemer’s agents: synthesis, in-silico and pharmacological evaluations

Figure 2

Behavioural study results: (a) Effect of compounds 8, 9, 10, 15, 16, 17, 18, 19 and 23 on escape latency compared to the scopolamine-treated group of mice. Values are expressed as Mean ± SD, n = 6. ####p < 0.0001 (positive control is compared with the normal control), ****p < 0.0001 (treatment groups are compared with positive control) (b) Effect of compounds 8, 9, 10, 15, 16, 17, 18, 19 and 23 on time spent compared to the scopolamine treated group of mice. Values are expressed as Mean ± SD, n = 6. ####p < 0.0001 (positive control is compared with the normal control), ****p < 0.0001 (treatment groups are compared with positive control).

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